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35 MYH9 participates in cancer development by performing various functions, such as a transcriptional factor and a deubiquitinase.26 Thus, the mechanisms by which MYH9 is involved in HCC stemness and LR are meaningful and interesting. Recent studies have focused on the role of MYH9 phosphorylation ...
As the PD-1 protein contains an extracellular domain, a transmembrane domain, and a cytoplasmic region35, we truncated PD-1 from its cytoplasmic tail and generated the PD-1-ΔC241-288 (deleting amino acid residues from 241 to 288) and ΔC192-288 (missing all cytoplasmic region) mutants, ...
2024;35(3):219–34. Article CAS PubMed Google Scholar Shi H, Gao Y, Dong Z, Yang J, Gao R, Li X, et al. GSDMD-Mediated cardiomyocyte pyroptosis promotes myocardial I/R Injury. Circul Res. 2021;129(3):383–96. Article CAS Google Scholar He X, Fan X, Bai B, Lu N, Zhang...
We detected the half maximal inhibitory concentrations (IC50) of docetaxel in PC3 (35.38 ± 0.98 nM) and DU145 (31.83 ± 0.96 nM) (Fig. S1). Cell proliferation assay demonstrated that the proliferation of PCa cells treated with 20 nM docetaxel increased after incubation with ...
Manipulation of USP18 expression not only induces possible anti-apoptotic activity in some cancers[35], but also change the tumor cell sensitivity to immunotherapy. Moreover, overexpression of USP18 in tumor cells may induce the immunesuppression activity of MDSC in tumor environment. Further studies...
Download all Document S1. Figures S1–S7 and Tables S4–S8 Table S1. Genes Targeted and shRNAs Used in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2 Table S2. DUBs Tested in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2...
Download: Download full-size image Fig. 3. Ectopic expression of SynUSP.HA at the N-terminus of UL36 cannot rescue defective in vitro replication of vC98A. (A) Schematic representation of pUL36 in vRB-1B, vC98A and vC98A-SynUSP.HA. (B) Plaque size analysis of vRB-1B, vC98A and ...
Oven: 35 °C (17 min) to 240 °C (5 min) @ 20 °C/min. Volatiles interface at a 5:1 split. Peak IDs for the Agilent 624 column: 1. methanol 2. 1,1 dichloroethene 3. acetonitrile 4. methylene chloride 5. Trans-1,2 dichloroethene 6. hexane 7. Cis-1,2 dichloroethene, ...