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Additionally, P53 is an important apoptosis-inducing protein [35,36,37,38,39,40,41]. Therefore, it is deduced that the inhibition of USP28 should lead to a reduction in P53-mediated apoptosis. However, some studies have indicated that USP28 deficiency leads to apoptosis [42]. The specific...
38 Silmitasertib (CX-4945), an oral CK2 inhibitor, has been approved by the FDA for cholangiocarcinoma (CCA) as an orphan drug. The application of CX-4945 effectively inhibited the development of CCA and suppressed HIF-1α expression.39These findings highlight the potential of CX-4945 as a...
8G, the volume of subcutaneous xenograft tumors derived from PC3/DU145-nano-siAGD1 cells was significantly reduced (from 938.67 ± 48.99 mm3 to 386.67 ± 48.29 mm3 in PC3, from 861.33 ± 72.67 mm3 to 451.67 ± 42.28 mm3 in DU145) with docetaxel treatment ...
Immunotherapy effectiveness is compromised because negative regulation mechanism in the immune system[10, 38]. Our study showed that USP18 expression in tumor cells significantly suppressed the expression of molecules responsible for inhibiting CTL activity during immunotherapy. Moreover enhancing USP18 ...
(C) Venn diagram of USP15 interactors for each condition (adjusted p value ≤ 0.05 compared to IgG; n = 4) showing the 38 common interactors. Italic text shows USP15 interactors not previously reported in the BioGRID database. Bold text shows known USP15 interactors according to the BioGRI...
For HCMV, both the non-cleaved form and a ∼38 kDa catalytic fragment were found to interact with an HA-tagged Ub-vinylmethyl esther (HAUbVME) DUB detection probe, previously used for identification of other USPs (Kattenhorn et al., 2005, Schlieker et al., 2005) and structural ...
Oct4 and Sox2 are regulated by the E3 ligase WWP2 during differentiation37,38. Klf4 is degraded by E3 ubiquitin ligase β-TrCP1 and β-TrCP2 (refs 28, 39). c-Myc is degraded by E3 ligase Fbxw7 during ESC differentiation40 and Rex1 is degraded by E3 ligase RNF12 (ref. 41). ...
(Wang et al., Sci Rep, 6, 26979, 2016b) The only example of structure-guided development of a DUB inhibitor, which targeted the SARs DUB PLPro (Baez-Santos et al., Antiviral Res, 115, 21-38, 2015), generated compounds with IC50s below 500 nM and exhibiting a high degree of ...