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A hallmark of tumor cells, including bladder cancer (BLCA) cells, is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which is crucial in regulating glycolysis, is amplified and activated in BLCA. However, d
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a recreation of the csgo model - CS:GO USP-S - Download Free 3D model by DFS studio (@DFS_studio)
PCSCs, characterized by self-renewal capability and multilineage differentiation potential, have garnered increasing attention [43]. However, PCSCs lack specific markers, making it challenging to isolate distinct sub-populations completely. To address this, serum-free DMEM/F12 medium supplemented with ep...
Previous studies have demonstrated that combinational therapy of PD-1 and CTLA-4 blockade is more effective than monotherapy in preclinical mouse tumor models and clinical trials42,43,44. We hypothesized that USP5 inhibition reducing PD-1 expression might improve the efficacy of anti-CTLA-4 immunoth...
The MYH9-S1943E mutant, had a more potent capability to bind HIF-1α than the MYH9-S1943A mutant (Fig. 5d). Moreover, MYH9-S1943E had a potent deubiquitination effect on the HIF-1α protein, while MYH9-S1943A did not (Fig. 5e). Furthermore, the wild type MYH9 and MYH9-S1943...
A recent study showed that USP19/NLRP3 axis shift macrophages polarization to M2 and thus promote anti-inflammatory response [43]. Wang et al. reported M2 macrophages polarization was inhibited by suppressing Ubc9 [44]. Another study proved that USP10 promotes M2 macrophages polarization by ...
This suggests that USP28 can affect the caspase cascade reaction [42,43,44]. Reports indicate that the overexpression of Noxa in tumors can significantly activate cell apoptosis, initiating the apoptosis process centered around the caspase cascade reaction[18]. In our study, the USP28 inhibitor ...
Digested the cells and prepared single-cell suspensions using serum-free culture medium. Adjusted the cell concentration to 1 × 104 cells/200 μL. For the invasion experiment, pre-coated the upper layer with 10 μg of 1 × Matrigel (Corning, New York, USA), added 200 μL of cell ...