To test whether plasma E 2 has a uricosuric effect we administered estradiol valerate and estradiol benzoate to either oophorectomized or adult women. Plasma E 2 levels and urinary total estrogen excretion increased significantly in both groups but the treatment failed to significantly modify serum...
et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417, 447–452 (2002). CAS PubMed Google Scholar Li, S. et al. The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 3, e194 (2007...
The serum creatinine, CyA dose and CyA blood levels remained unchanged. In conclusion, hyperuricemia is a frequent complication in transplant patients on treatment with CyA. Our data suggest that the disorder could be due to an impairment of the tubular secretion of urate. Benziodarone is an ...
Barriers to regular ULT use include understanding the need to take daily long-term medication; attendances for blood-testing for serum urate levels and for titrating the drug dose; obtaining regular three-monthly repeat prescriptions, and remembering to take daily medication [7]. There are costs ...
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Clearance studies using the URAT1 inhibitor benzbromarone (100 mg/day) or losartan (50 mg/day) loading test were also performed in these patients. RESULTS: Blood pressure (BP) significantly decreased in the patients treated with either losartan or candesartan. Losartan significantly reduced Sur, ...
(PCROSS = 1.43 × 10−10,PEUR = 3.99 × 10−9,PEAS = 2.54 × 10−4). Cardiovascular system-related tissues, such as heart valves, were significantly enriched in the European ancestry only (P = 6.07 × 10−4). The fetal blood of the ...
were able to demonstrate that blood pressure levels were predictive for cardiovascular disease incidence synergistically with serum uric acid level [27]. Two separate laboratories have demonstrated the development of systemic hypertension in a rat model of hyperuricemia developed with a uricase inhibitor ...
blood. Whole genome bisulfite sequencing (WGBS) of kidney samples (n = 5) showed lower DNA methylation levels at the urate-associated CpGs in the promoter-associated region of isoform 1, and the pattern of DNA methylation level aligned with gene expression levels from RNA-sequencing (Fig....
Also provided is a method of reducing uric acid levels in a biological fluid of a subject in need thereof, comprising administering the pharmaceutical composition comprising the uricase of the invention. In a particular embodiment, the biological fluid is blood. In an embodiment, the uricase compr...