ObjectivesTwenty-eight genetic loci are associated with serum urate levels in Europeans. Evidence for association with gout at most loci is absent, equivocal or not replicated. Our aim was to test the loci for association with gout meeting the American College of Rheumatology gout classification crit...
ObjectiveTo assess the proportion of, and factors associated with, older adults with gout receiving a serum urate (SUA) test after starting urate-lowering therapy (ULT). MethodsWe performed a population-based retrospective cohort study in Ontario, Canada in patients ages & GE;66 years with gout...
Assessment of Serum Levels of Urea ,Creatinine and Urate among Type II Diabetic Patients With Myocardial Infarction Across –sectional study conducted during the period from May 2012 to August 2012 to asses and compare the serum levels of urea ,creatini... RHA Murrds - Sudan University of Scien...
Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study [J]. Int J Epidemiol. 2023;52(1):178–89. Article PubMed Google Scholar Piao W, Zhao L, Yang Y, et al. The Prevalence of Hyperuricemia and Its ...
Serum urate (SU) is known to cause gout if a high SU level (hyperuricemia) is maintained1. It is associated with several diseases, including nephrolithiasis, hypertension, and cardiovascular disease2,3,4. According to guidelines from the American College of Rheumatology5, urate-lowering therapeutics...
Although a meta-analysis by Chen et al35 failed to note sufficient evidence of improvement in kidney function outcomes following urate-lowering therapy, urate-lowering therapy attenuated the decrease in the slope of eGFR. Based on the fact that most studies assessing the role of SUA level–...
Rathmannet al. found that the BMI in all race-sex-groups significantly increased with increasing uric acid level25. Furthermore, not only elevated SUA concentrations were associated with the increasing risk of obesity, but obesity was also associated with higher risk of hyperuricemia. For example,...
Serum antioxidant (urate, α-tocopherol) activity and cholesterol concentration in 142 patients of Indian and Arab (Kuwaitis and other Arabs) origin with d... Y Goto - 《Int Symp Atherosscler Abstr》 被引量: 40发表: 1982年 Serum cholesterol levels of males and females in different age group...
Lowering serum urate does not improve endothelial function in patients with type 2 diabetes Diabetologia, 50 (2007), pp. 2572-2579 Google Scholar 33 Y.T. Wun, C.S. Chan, C.S. Lui Hyperuricaemia in type 2 diabetes mellitus Diabetes Nutr Metab, 12 (1999), pp. 286-291 Google Scholar ...
proposed urate-binding residues (orange); and the PDZ domain binding motif (purple).bAbundance of URAT1 mutant constructs in HEK293T cells, glycosylation revealed with PNGase, and summary data;n = 4 to 12; ±SEM; *p < 0.0001 (ANOVA with Dunnett’s multiple comparison test). Each...