Skip to main contentSkip to article Journals & Books Help Search My accountSign in View PDF Download full issue Search ScienceDirect The Kaohsiung Journal of Medical Sciences Volume 28, Issue 5, May 2012, Pages 259-264
et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat. Genet. 50, 1505–1513 (2018). CAS PubMed PubMed Central Google Scholar Benner, C. et al. FINEMAP: efficient variable selection using summary data ...
its high concentrations in cerebrospinal fluid (csf) and blood have been attributed to a mutation in the urate oxidase gene occurring late in hominid evolution. oxidative damage is suspected to contribute to the neurodegenerative process in parkinson disease (pd), and antioxidants like urate may ...
East Asian ancestry (N = 219,768) analyses, respectively (Supplementary Data2,3, and4). The genetic correlation of SU between the two ancestries was estimated to be high (ρge = 0.942, standard error [s.e.] = 0.079) using Popcorn19(Supplementary Data5). The effect size...
Although the study focuses on Pacific people, Māori have similar issues with a high prevalence of gout and their ULT uptake could also be improved. These innovative interventions are therefore likely to translate to Māori health care, and possibly to the management of gout patients of other ...
[22]. Interestingly, it has been shown that application of urate prevents liver neutrophil infiltration and injury during hemorrhagic shock [23] and inhibited tyrosine nitration to preserve the integrity of the blood–brain barrier by blocking the entry of inflammatory cells into the central nervous ...
(p-value < 1.9E-03, 0.05/26). Effect sizes of the genetic associations on serum urate were of similar magnitude in the GCKD study and the population-based meta-analysis for most SNPs, with high correlations across all risk variants observed for both urate (Pearson correlation ...
However,SLC2A9is expressed in a range of extra-renal tissues, with high abundance in the liver and lower abundance in the heart, lung, and intestine59,60,61. In mouse hepatocytes, GLUT9 is expressed in the basolateral membrane60, across which urate uptake from blood into the cell can occu...
Goldman SC et al., A Randomized Comparison Between Rasburicase and Allopurinol in Children with Lymphoma or Leukemia at High Risk for Tumor Lysis, Blood 2001, 97 (10): 2998-3303. Kissel P. et al., Modificaiton of Uricaemia and the Excretion of Uric Acid Nitrogen by an Enzyme of Fungal...
Sherman, M., et al., “Conjugation of High-Molecular Weight Poly(ethylene glycol) to Cytokines: Granulocyte-Macrophage Colony-Stimulating Factors as Model Substrates,” in: ACS Symposuim Series 680. Poly(ethylene glycol). Chemistry and Biological Applications, pp. 155-169, Harris, J. and Zalip...