Thus, there is a need for a safe and effective alternative means for lowering elevated levels of uric acid in body fluids, including blood. The present invention provides a mutant recombinant uricase, wherein the uricase has been truncated by 1-20 amino acids at either the amino terminus or...
This study provides valuable insights into the genetics and biology of SU and its related diseases. The cross-ancestry meta-analysis results were enriched in most tissues, including the urinary tract of the urogenital system, kidney, and cartilage and exhibited the lowestP-values. In addition, we...
An important function of DNA methylation is the regulation of gene expression25. To determine whether the urate-associated CpGs were associated with gene expression in blood cells, we used summary statistics of DNA methylation and gene expression from monocytes and whole blood. Gene expression in mon...
In a particular embodiment, the biological fluid is blood.In an embodiment, the uricase comprises a peptide having the sequence of position 44 to position 56 of Pig-KS-ΔN (SEQ ID NO. 14).In an embodiment, the uricase protein comprises an N-terminal methionine. In a particular embodiment...
The kidney has a fundamental role in whole body homeostasis1. It is essential in filtering blood and actively reabsorbing and secreting solutes, metabolites and proteins during tubular passage. The importance of tubular kidney function is illustrated by the regulation of urate metabolism. Serum urate...