In this study, we identified ubiquitin-specific protease 1 (USP1) as an oncogene with essential roles during hepatocellular carcinoma (HCC) progression. USP1, with elevated expression levels and clinical significance, was identified as a hub DUB for HCC in multiple bioinformatics datasets. ...
Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend to accumulate under pathological conditions. Ubiquitin-specific protease (USP) is the largest deubiquitinating enzyme family and a...
Ubiquitin-specific-processing protease 1推荐供应商 我要询价 西格玛奥德里奇(上海)贸易有限公司 联系电话:21-20338288 电子邮件:ordercn@merckgroup.com CB指数:58 网址:www.sigmaaldrich.cn 相关信息:产品目录(292394) 用户评价 英文名称:Anti-USP1 (N-term) antibody produced in rabbit ...
A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs 2000, Journal of Biological Chemistry Citation Excerpt : Several independent clones were sequenced on both DNA strands using an automated DNA sequencer to exclude any PCR error, and all restriction sites used f...
and deubiquitination have provided novel insights. Targeting the ubiquitin-specific protease (USP) family of deubiquitinases elucidates IBD signalling pathway mechanisms and possibly, IBD therapeutic solutions. Here, we characterised USPs as chief regulators of pro-inflammatory signalling pathways, including ...
In their study, Carrà and colleagues have shown that the p190 BCR-ABL fusion protein, through its interaction with the deubiq- uitinase known as herpesvirus-associated ubiquitin-spe- cific protease (HAUSP), can induce the destabilization and subsequent downregulation of the p53 protein [48]. ...
[19,20]. USPs are characterized by the presence of a conserved catalytic domain known as the USP domain, which exhibits protease activity and enables the cleavage of ubiquitin from target proteins. In addition to the USP domain, various USPs possess additional domains or motifs, such as ...
Nuclear factor TAK1: Transforming growth factor beta activated kinase 1 TGFβ: Transforming growth factor beta UCH: Ubiquitin C-terminal hydrolase USP: Ubiquitin-specific protease References Hershko A, Ciechanover A: The ubiquitin system. Annu Rev Biochem. 1998, 67: 425-479. 10.1146/annurev...
Nuclear factor TAK1: Transforming growth factor beta activated kinase 1 TGFβ: Transforming growth factor beta UCH: Ubiquitin C-terminal hydrolase USP: Ubiquitin-specific protease References Hershko A, Ciechanover A: The ubiquitin system. Annu Rev Biochem. 1998, 67: 425-479. 10.1146/annurev...
As aforementioned, USPs are a class of cysteine-dependent proteases, an analogous mechanism of action of the cysteine protease papain. The catalytic domain (or USP domain) is the most conserved domain among USPs that can vary in size from less than 300 to more than 800 amino acids; the ...