Ubiquitin-specific protease 15 negatively regulates virus-induced type I interferon signal- ing via catalytically-dependent and -independent mechanisms. Sci Rep 2015; 5:11220.Ubiquitin-specific protease 15 negatively regulates virus-induced type I interferon signaling via catalytically- dependent and -...
Ubiquitin-specific protease 22 promotes the proliferation, migration and invasion of glioma cells Cancer Biomark., 23 (3) (2018), pp. 381-389 CrossrefView in ScopusGoogle Scholar [86] K. Xu, H. Pei, Z. Zhang, H. Wang, L. Li, Q. Xia Ubiquitin-specific protease 15 promotes tumor cell...
Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend to accumulate under pathological conditions. Ubiquitin-specific protease (USP) is the largest deubiquitinating enzyme family and a...
Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend to accumulate under pathological conditions. Ubiquitin-specific protease (USP) is the largest deubiquitinating enzyme family and a...
and deubiquitination have provided novel insights. Targeting the ubiquitin-specific protease (USP) family of deubiquitinases elucidates IBD signalling pathway mechanisms and possibly, IBD therapeutic solutions. Here, we characterised USPs as chief regulators of pro-inflammatory signalling pathways, including ...
The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia. Oncol Lett. 2016;12(5):3123–6. 49. Peiris MN, Meyer AN, Warda D, Campos AR, Donoghue DJ. Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-...
[19,20]. USPs are characterized by the presence of a conserved catalytic domain known as the USP domain, which exhibits protease activity and enables the cleavage of ubiquitin from target proteins. In addition to the USP domain, various USPs possess additional domains or motifs, such as ...
Ubiquitin-specific protease 15 The USP15 gene is found amplified in around 2% of human breast tumors as well as other tumors, including ovarian and glioblastoma tumors [21]. Recent data implicate USP15 as an important regulator of cell cycle progression [31]. In glioblastomas, USP15 is report...
already preformed and the protease might be active in the absence of the SUMO substrate, in contrast to the apo structures of other UPSs, such as USP7, USP15, and USP18, in which binding of the ubiquitin substrate is necessary to rearrange the catalytic triad to an active conformation15,...
Ubiquitin-specific protease 15 The USP15 gene is found amplified in around 2% of human breast tumors as well as other tumors, including ovarian and glioblastoma tumors [21]. Recent data implicate USP15 as an important regulator of cell cycle progression [31]. In glioblastomas, USP15 is report...