Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIBAlthough there have been advances in understanding colorectal cancer (CRC) pathogenesis, significant gaps still exist, highlighting the need for ...
MutS homolog 2%clinical implication%human ubiquitin-specific protease 10%non-small cell lung cancer Previous studies have indicated that USP10 stabilizes and deubiquitinates MutS homolog 2 (MSH2) in in vitro and in vivo models. The level of MSH2 ... Zhi,Zeng,Dan,... - 《Oncology Letters》...
As the largest family of DUBs, USPs bear both similarities with, and critical differences from, the other cysteine protease DUBs. All DUB catalytic domains contain a primary ubiquitin-binding site that enables numerous interactions with ubiquitin in the distal region of a polyubiquitin chain [6]. ...
公开/公告日期: 1991-11-10 申请(专利权)人: MASSACHUSETTS INST TECHNOLOGY 发明人: VARSHAVSKY Alexander J. One longfellow Place,TOBIAS John W.摘要: ubiquitin specific protease, which cleaves ubiquitin from any protein or any peptide to which the ubiquitin is joined, and the gene encoding the ...
Ubiquitin-specific protease-regulated signaling pathways implicated in breast cancer Ubiquitin-specific proteases overexpressed in breast cancer Other ubiquitin-specific proteases implicated in breast cancer: USP9X, USP10 and USP25 Small molecule inhibitor-mediated targeting of ubiquitin-specific proteases Conclu...
Protein ubiquitination and deubiquitination are reversible processes, which can modulate the stability, activity as well as subcellular localization of the substrate proteins. UBIQUITIN-SPECIFIC PROTEASE (UBP) protein family participates in protein deubiquitination. Members of UBP family are involved in a va...
Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A. J Biol Chem 2011; 286: 38960–38968. Article CAS Google Scholar Wessel D, Flügge UI . A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal ...
Protease SUMO Ubiquitin Viruses 1. Introduction In the course of evolution viral and bacterial pathogens have acquired a series of molecular strategies to promote infection, proliferation and survival during host–pathogen interactions. This aspect has been of considerable interest over many years, since...
Ubiquitin-specific protease-regulated signaling pathways implicated in breast cancer Ubiquitin-specific proteases overexpressed in breast cancer Other ubiquitin-specific proteases implicated in breast cancer: USP9X, USP10 and USP25 Small molecule inhibitor-mediated targeting of ubiquitin-specific proteases Conclu...
cysteine-dependent proteases, an analogous mechanism of action of the cysteine protease papain, which features three highly conserved subdomains resembling the fingers, thumb, and palm of the right hand [19,20]. USPs are characterized by the presence of a conserved catalytic domain known as the ...