The ubiquitin-specific protease, USP7, has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. We show that the N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2, falling between p53 residues 359-367 and MDM2 residues 147-159. ...
Among the USPs, ubiquitin-specific protease 7 (USP7) stands out as a well-studied cysteine protease with the ability to modulate multiple cellular proteins involved in various pathways, including viral replication, immune response, apoptosis, DNA damage and repair, and epigenetic regulation [13,14,...
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapyResistance of acute myeloid leukemia (AML) to therapeutic agents is frequent. Consequently, the mechanisms leading to this resistance must be understood and addressed. In this paper, we demonstrate that inhibition...
产品名称: Ubiquitin Specific Protease 7 (herpes Virus-associated) (USP7) Rabbit anti-Human Polyclonal Antibody .0 订购此产品 供应商: Lifespan 规格: 50ul 目录价: ￥:4550 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: 保存条件: 说明书地址: 点击查看详细 打印此页 关闭此页 上一...
P5091,Ubiquitin-specificProtease7(USP7)Inhibitor的详细介绍 Product Information Molecular Weight:348.22 Formula:C12H7Cl2NO3S2 Purity:≥98% CAS#:882257-11-6 Solubility:DMSO up to 100 mM Chemical Name:1-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone ...
Ubiquitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its downstream regulator, E3 ubiquitin ligase Mdm2. Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xeroderma pigmentosum complementation group C (XPC) protein,...
服务地域:全国 品牌:MedChemExpress (MCE) 产地:美国 厂商性质:生产商 货期:现货 规格:0 近期咨询:1MedChemExpress (MCE) 普通会员 进入商铺 全部产品 产品特点 产品描述 Ubiquitin-Specific Protease 7 蛋白 MCE 国际站:Ubiquitin-Specific Protease 7 品牌:MedChemExpress (MCE) 相关产品:USP7 蛋白, Human ...
Targeting the ubiquitin-specific protease (USP) family of deubiquitinases elucidates IBD signalling pathway mechanisms and possibly, IBD therapeutic solutions. Here, we characterised USPs as chief regulators of pro-inflammatory signalling pathways, including nuclear factor-κB and transforming growth factor-...
中文名称:泛素特异性蛋白酶7抑制剂(USP7抑制剂)(P22077) 中文同义词:泛素特异性蛋白酶7抑制剂(USP7抑制剂)(P22077) 英文名称:ubiquitin-specific protease USP7 inhibitor 英文同义词:ubiquitin-specific protease USP7 inhibitor CAS号: 分子式: 分子量:0 ...
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells The family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a variety of cellular processes. The human genome contain... H Ovaa,BM Kessler,Ulrika Rolen,....