生化机理 标准磷脂酶C抑制剂(PLC)(PLC-β3时IC 50 =〜6 µM)。显示多种生物活性,包括抗血小板激活,Ca 2+信号传导调节和抑制5-脂氧合酶活性。体内具有活性 储存温度 -20°C储存 运输条件 超低温冰袋运输 备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备...
产地:BIOMOL 货号规格:BML-ST391-0025 25 mg BML-ST391-0005 5 mg 名称:U-73122 Inhibits agonist induced phospholipase C (PLC) activation (IC50=1-2.1 µM) in human platelets. It also inhibits agonist induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. It is a ...
U73122 is often used as a selective amino-steroid phospholipase C(PLC) inhibitor,which has been widely applied to exclude intracellular Ca~(2+) release from InsP_3 sensitive storage sites from the triggered increase in[Ca~(2+)]_i.InsP_3 is the downstream product of PLC and blockade of ...
has no obvious influence ell the growth of RPE cells and the secretion of TGF一132. Key words RPE cells;transfer growth factor一92;phospholipase inhibitor;adenylate cyclase inhibitor 摘要 目的观察磷脂酶c(PLC)抑制剂U73122和腺苷酸环化酶(AC)抑制剂SQ22536对豚鼠视网膜色素上皮 (RPE)细胞增生及分泌...
The left panel: conditioned medium from A431 cells, control and treated with U73122 PLC inhibitor, was passed over the ATP-agarose column and the eluted protein was subjected to immunoblotting, using 2H9 antibody. The central and right panels: samples of conditioned medium were incubated with ...
The aminosteroid U73122 inhibited phospholipase C (PLC)-mediated intracellular Ca2+ release in differentiated and undifferentiated NG108-15 cells, as well ... W Jin,TM Lo,HH Loh,... - 《Brain Research》 被引量: 240发表: 1994年 Inhibitory effects of U73122 and U73343 on Ca2+ influx and...
U73122 has been widely used as a selective PLC inhibitor. In the present study, the effects of U73122 on platelet function have been further examined. Platelets were stimulated with collagen (via PLC-纬), the stable thromboxane mimetic U46619 (via PLC-尾), or phorbol myristate acetate (PMA)...
Antiinflammatory U-73122 U73122 PLC inhibitorHou, C
We found that 1-[6-[[17尾-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122), an inhibitor of phospholipase C (PLC), suppressed both opsonized zymosan (OZ)-induced dephosphorylation and translocation of cofilin in macrophage-like U937 cells at 4 渭M ...
Unexpectedly, U73343, a close analog of U73122 which lacks PI-PLC inhibitory activity also promotes OL differentiation, while another reported PI-PLC inhibitor edelfosine does not have such effect, suggesting that U73122 and U73343 enhance OPC differentiation independent of PLC. Although the ...