Afatinib is an oral epidermal growth factor receptor tyrosine kinase inhibitor targeting the ERBB family (including EGFR, HER2, ERBB3, and ERBB4), and has been approved for the treatment of locally advanced or metastatic non-small-cell lung cancer (NSCLC) with an EGFR-sensitive mutation [22]....
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo Blood, 116 (22) (2010), pp. 4578-4587 View PDFView articleCrossrefView in ScopusGoogle Scholar 16 M Kwok, N Davies, A Agathanggelou, et al. ATR inhibition induces synthetic ...
P5091, as a novel specific inhibitor of USP7, might have clinical significance by providing an effective way to treat GBM. It is well known that GBM is an incurable malignant brain tumor due to its high cellular heterogeneity, caused by the complex brain genetic heterogeneity of patients [71...
TP53-regulated apoptosis inhibitor 1(referred to as TRIAP1 or P53CVs), upregulated by TP53 in response to low genotoxicity, is a necessary protein for the maintenance of mitochondrial morphology and is mainly involved in the cellular survival pathways regulated by TP53 [20]. Mechanistically, TRIAP...
Melatonin enhances the anti-proliferative action of β-catenin or HDACs inhibitor on ESCC cells To further understand the role of β-catenin on mediating HDAC7-induced c-Myc upregulation, the specific β-catenin activity inhibitor Lf3 was applied to the ESCC cells, and Lf3 treatment dose-depende...