The combinational treatment of USP7 inhibitor and CDK1 inhibitor with lower doses synergistically repressed the ERPBC proliferation and metastasis and further provided a potential therapeutic strategy in clinical breast therapy. Targeting CDKs may have unintended consequences because they play an important...
P5091, as a novel specific inhibitor of USP7, might have clinical significance by providing an effective way to treat GBM. It is well known that GBM is an incurable malignant brain tumor due to its high cellular heterogeneity, caused by the complex brain genetic heterogeneity of patients [71...
TP53-regulated apoptosis inhibitor 1(referred to as TRIAP1 or P53CVs), upregulated by TP53 in response to low genotoxicity, is a necessary protein for the maintenance of mitochondrial morphology and is mainly involved in the cellular survival pathways regulated by TP53 [20]. Mechanistically, TRIAP...