We have used mass spectrometry and X-ray crystallography to demonstrate that tyrosine autophosphorylation of the catalytic tyrosine kinase domain of FGF-receptor-1 (FGFR1) is mediated by a sequential and precisely ordered reaction. We also demonstrate that the rate of catalysis of two FGFR substrates...
signaling cascades 网 络 诱使细胞内信息传导 双语例句 1. To study the role of adaptor protein Bam 32 in B cell antigen receptor ( BCR ) signaling cascades. 目的:研究接头蛋白(adaptorprotein)Bam32在B细胞抗原受体 ( Bcellantigenrece。
This prevents receptor tyrosine kinase activation, and attenuates EGFR-mediated intracellular signaling. Numerous MoAbs to the EGFR have been developed over the past two decades, but only cetuximab and panitunumab have received US Food and Drug Administration (FDA) approval so far, for the treatment...
酪氨酸激酶受体 ( tyrosine kinase receptor ) 答案 酪氨酸激激酶受体: 为膜上的一种特殊蛋白质, 只有一个跨膜螺旋和一个较 短的膜内肽段, 当膜外的肽段同相应的化学信号结合时, 可以直接激活膜内侧肽 段的蛋白激活活性,由此再引发各种细胞内功能的改变。 结果二 题目 酪氨酸激酶受体< tyrosine kinase recept...
LeadingEdge Review Cell141,June25,2010©2010ElsevierInc.1117 Sincethediscoveryo therstreceptortyrosinekinase(RTK)more thanaquartero acenturyago,manymemberso this amilyo cell-sur acereceptorshaveemergedaskeyregulatorso critical cellularprocesses,suchasproli erationanddi erentiation,cell survivaland...
A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-γ, and the Jak/STAT pathways. The precise ...
Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the ras signaling pathway. Thus, tyrosine kinase inhibitors can inhibit proliferation of breast cancer cells, accompanied by inhibition of signal transduction steps potentially mediated ....
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases. Signaling through receptor tyrosine kinases (RTKs) is a major mechanism for intercellular communication during development and in the adult organism, as we... A Ostman,Bhmer FD - 《Trends in Cell Biology》 被引量: ...
The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an RTK...
2010. The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling. PLoS One 5,e14412.DRAFAHL KA,MCANDREW CW,MEYER AN,et al.The re- ceptor tyrosine kinase FGFR4 negatively regulates NF-kappa B signaling[J].PIos One,2010,5(12):doi:10.1371/Joumai.pone.0014412....