protein modification that controls the degradation,localization,transport,activity and complex formation of protein(s).E3 ubiquitin ligases,including the single subunit E3s and the multi-subunit E3 ubiquitin ligase complexes,play crucial roles in the regulation of both innate and adaptive immune response....
An E3 ubiquitin ligase mediates the transfer of activated ubiquitin from an E2 ubiquitin-conjugating enzyme to its substrate lysine residues. Using a struc... DE Christensen,PS Brzovic,RE Klevit - 《Nature Structural & Molecular Biology》 被引量: 557发表: 0年 RNF4-Dependent Hybrid SUMO-Ubiquiti...
The tumor-suppressor p53 similarly appears to be retained in the cytoplasm by the ubiquitin ligase p53-associated Parkin-like cytoplasmic protein (Parc) in the absence of stress stimuli [82]. Moreover, a recent report demonstrated that arginine-rich dipeptide repeat proteins (DPRs) bind directly ...
The E3 ubiquitin ligase Parkin (PARK2) and the protein kinase PINK1 (PARK6) are mutated in autosomal recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy1–3. PINK1 is stabilised ... T Wauer,M Simicek,A Schubert,... - 《Nature》...
Both wild type and mutant E6AP that lacks the ubiquitin ligase activity were capable to stabilize E6 and augment Wnt/β-catenin transcription. The ability of E6AP to elevate β-catenin/TCF transcription correlated with the ability of E6AP to associate with E6, showing higher ability with the ...
- 《International Journal of Cancer》 被引量: 211发表: 2003年 Kinetic Analysis of the Interactions of Human Papillomavirus E6 Oncoproteins with the Ubiquitin Ligase E6AP Using Surface Plasmon Resonance Cervical cancers evolve from lesions generated by genital human papillomaviruses (HPV). "Low-risk" ...
As a downstream target gene of FOXM1 (Zhang et al. 2018a), ubiquitin conjugating enzyme E2 C (UBE2C) encodes a member of the E2 ubiquitin-conjugating enzyme family catalyzing the ubiquitination and degradation of cyclin A and B, collaborating with the E3 ligase of the anaphase-promoting comp...
Orum Therapeutics' technology, which also combines protein degraders coupled to antibodies, is similar in conception to that of Debiopharm and Ubix, particularly the degraders, both of which have a ubiquitinase degradation mechanism of action. However, the two also differ, with Orum Therapeutics defin...
The E4orf6 protein of serotypes representing all human adenovirus species forms Cullin-based E3 ubiquitin ligase complexes that facilitate virus infection by inducing degradation of cellular proteins that impede efficient viral replication. This complex also includes the viral E1B55K product believed to...
Zhang Y, Higashide WM, McCormick BA, Chen J, Zhou D: The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase. Mol Microbiol. 2006, 62: 786-793. 10.1111/j.1365-2958.2006.05407.x. Article CAS PubMed Google Scholar Studholme DJ: Enhancer-dependent transcription in Salm...