This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.DOI: 10.1016/j.cell.2016.03.003 被引量: 16 ...
protein modification that controls the degradation,localization,transport,activity and complex formation of protein(s).E3 ubiquitin ligases,including the single subunit E3s and the multi-subunit E3 ubiquitin ligase complexes,play crucial roles in the regulation of both innate and adaptive immune response....
The protein catabolism category includes 27 mRNAs that encode ubiquitin ligases, ubiquitin proteases, or proteins that support ubiquitination in other ways; all functions that are likely to be required in both mature and immature OSNs. These biases in expression toward either end of the ...
Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of s... W Jin,M Chang,SC Sun - 《Cellular ...
et al. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol. Cell 14, 395–403 (2004). Article CAS PubMed Google Scholar Latres, E. et al. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy...
Molecular CellShimizu Y, Okuda-Shimizu Y, Hendershot LM (2010) Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids. Mol Cell 40(6):917–926 CentralShimizu Y, Okuda-Shimizu Y, Hendershot LM. Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids....
The gut epithelium is subject to constant renewal, a process reliant upon intestinal stem cell (ISC) proliferation that is driven by Wnt/β-catenin signaling. Despite the importance of Wnt signaling within ISCs, the relevance of Wnt signaling within other gut cell types and the underlying mechanis...
Regulation of cellular signalling pathways by Adenovirus This is achieved, in part, by the ability of viral E1B55K and E4ORF6 proteins to hijack host cell cullin-containing E3 ubiquitin ligase complexes and... NA Forrester - 《University of Birmingham》 被引量: 0发表: 2012年 加载更多来源...
Epigenetic processes also regulate NOS isoforms. The proximal promoter of the Nos3 gene is non-methylated in endothelial cells, but heavily methylated in non-endothelial cell types [1174]. Transcription factors — E26 factor ETS1 and specificity proteins SP1 (stimulatory) and SP3 (inhibitory) — ...
Additionally, LSD2 extends beyond histone demethylation, impacting DNA methylation, cancer cell reprogramming, E3 ubiquitin ligase activity and DNA damage repair pathways. This study underscores the distinct roles of LSD2, providing insights into their contributions to cancer and other...