When subdivided, drugs with oligonucleotides alone as the payload also give rise to a variety of conceptual products. Fig 15. Antibody-oligonucleotide conjugates (AOC), Source: avidity biosciences website Avidity has also developed the AOC product AOC1001 based on this concept for the treatment of...
The mammalian brain is composed of a large number of highly diverse cell types with different molecular, anatomical, and functional features. Distinct cellular identities are generated during development under the regulation of intricate genetic programs and manifested through unique combinations of gene ex...
Oligonucleotides APOE sgRNA oligomer pair (Forward): 5′-CACCGCCTCGCCGCGGTACTGCACC-3′ This paper N/A APOE sgRNA oligomer pair (Reverse): 5′-AAACGGTGCAGTACCGCGGCGAGGC-3′ This paper N/A ssODN for APOE3 -> APOE4: 5′- GAGGAGACGCGGGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCCCGGCTGGGCGCGGACAT...
The use of anti-sense oligonucleotides or ribozymes to prevent the expression of particular genes in cultured cells, and of “gene knock-out” experimental animals, provide valuable experimental tools. However, they are not easily applicable to human therapy. We are exploring the use of small ...
Both SCGB2A1-specific siRNA oligonucleotides (ID s8730) and non- specific siRNA duplexes used as negative control were purchased from Ambion (Austin, TX, USA). Briefly, SCGB2A1-positive metastatic ovarian carcinoma cells were cultured in six-well plates and transfected with anti-SCGB2A1 siRNA ...
Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy Loss of Survival Motor Neuron-1 (SMN1) causes Spinal Muscular Atrophy, a devastating neurodegenerative disease. SMN2 is a nearly identical copy gene; however SMN2 cannot prevent diseas...
Antisense oligonucleotides initially offered great hope as specific compounds to modify gene expression, primarily through RNaseH induced degradation of th... Steve,D,Wilton,... - 《Current Gene Therapy》 被引量: 72发表: 2005年 Pharmacological read-through of nonsense ARSB mutations as a potential...
9. Thermoresponsive cell culture microcarriers for large-scale cell cultivation 10. Thermoresponsive surfaces for bio-separation 11. Applications of thermoresponsive surfaces in tissue engineering 12. Applications of thermoresponsive surfaces for regenerative therapy 13. Conclusions Conflict of interest Acknowledge...
Virus Genes;15:33-37 - Stram () Citation Context ...bolic half-life and lower toxicity than completely thioated oligonucleotides. Anti-FMDV ribozymes have been used for efficient cleavage of FMDV RNA in the VP3, VP4 and viral polymerase- coding region =-=(63)-=-. Effectiveness of ...
20100062518 Concentrating White Blood Cells for DNA Extraction from a Leukodepleted Blood Sample March, 2010 Banerjee 7615345 Arrays formed of encoded beads having oligonucleotides attached November, 2009 Seul 7595279 Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bo...