Recently, bridged nucleic acids have come to be more utilized as one of the promising components of therapeutic oligonucleotides. Oligonucleotides containing 2′-O,4′-C-ethylene-bridged nucleic acid (ENA) have been synthesized as functional oligonucleotides to further optimize the 2′-O,4′-C-...
However, this is still a maturing paradigm for the biopharmaceutical industry and new challenges are constantly being addressed, some unique to oligo and long nucleic acid products and some shared with other biotherapeutic modalities. How To Synthesize Oligonucleotides Example: Chemical S...
Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents The detection of gallium in biological samples is required due to its role in the diagnosis of tumor and for possible treatment of malignancies. However, the use of purely instrumental techniques...
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S − )O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA bind...
Find purpose-built phosphoramidites and custom services in nucleic acid chemistry for synthesis of oligonucleotides for diagnostic and therapeutic applications.
Oligonucleotides constitute a class of potential therapeutic agents.Improvement of certain properties,such as cell-specific delivery,cellular uptake efficiency,intracellular distribution,and target specificity can be accomplished by covalent association to peptides....
The chemical ligation of shorter oligos using click chemistry overcomes these problems. It could be used in total synthesis of very long strands of DNA including synthetic genes. The delivery of therapeutic oligonucleotides [7, 8] and the chemical evolution of oligonucleotide therapies of clinical ...
It is therefore unsurprising that synthetic analogues of nucleosides and their derivatives have emerged as a versatile class of drug molecules for the treatment of a wide range of disease areas. Despite their great therapeutic potential, the dense arrangements of functional groups and stereogenic ...
The research projected a compound annual growth rate (CAGR) of 16.8 percent from $7.7 billion in 2022. Synthesised oligonucleotides Therapeutic applications in this field include antisense oligonucleotide-based therapies, siRNA oligonucleotide-based therapies and cytosine-phosphorothioate-guanine (CpG) olig...
Oligo Factory offers oligonucleotide synthesis services for research and clinical applications, including custom oligos for DNA and RNA synthesis.