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Single-cell messenger RNA sequencing reveals rare intestinal cell types. Understanding the development and function of an organ requires the characterization of all of its cell types. Traditional methods for visualizing and isol... Dominic,Grün,Anna,... - 《Nature》 被引量: 356发表: 2015年 Re...
The rapid accumulation of the whole genome sequencing (WGS) and the whole exome sequencing (WES) data has led to the discovery of a tremendous number of genetic variations, both pathogenic and non-pathogenic. To aid the assessment and understanding of these variations, population databases such ...
The HPV L1 gene was amplified by PCR using original and modified GP5+/6+ primers. Amplified PCR products were genotyped by the microarray system GeneSquare (KURABO) and/or clonal sequencing. Of the 281 women, 139 (49.5%) were positive for HPV DNA. Among the HPV-positive samples, 339 ...
2015. Single-cell messenger RNA sequencing re- veals rare intestinal cell types. Nature 525: 251-255.Grun D, Lyubimova A, Kester L, Wiebrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature. 2015;525(...
Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. Existing methods for detecting DNA modification from nanopore sequencing data do not effectively support de novo study of unknown bacterial methylomes. In this work, ...
CPM-TMM normalized gene counts across technical replicates for a given biological replicate were averaged for the count tables used in all analyses performed. Sequencing batches and plasma volumes were obtained from the authors in Toden et al. and Chalasani et al. for per-sample normalization. For...
Using single-cell RNA sequencing (scRNA-seq), Tsukui et al. recently classified collagen-producing cells in the mouse and human lung as peribronchial fibroblasts, adventitial fibroblasts, alveolar fibroblasts, pericytes, and smooth muscle cells, but their role in epithelial regeneration is unclear28....
Cucumber, Cucumis sativus L., is an economically and nutritionally important crop of the Cucurbitaceae family and has long served as a primary model system for sex determination studies. Recently, the sequencing of its whole genome has been completed. However, transcriptome information of this species...
We identified small insertions or deletions in five of these cell strains, but we could not identify the mutation in the sixth individual. Thus, although as many as one-half of the mutations that give rise to EDS types I and II are likely to lie in the COL5A1 gene, a significant ...