DUNLAP, K. Functional and pharmacological differences between two types of GABA receptors on embryonic chick sensory neurons. Neurosci. Lett. 47: 265-270, 1984.Dunlap K. (1984). Functional and pharmacological differences between two types of GABA receptor on embryonic chick sensory neurons. Neurosci...
Blockade of GABA A receptors with bicuculline (20 M) led to decreases in the numbers of slow and two-component mIPSP and an increase in the number of mIPSP with fast kinetics. Strychnine (1 M), a blocker of glycine receptors, led to a reduction in the number of fast receptors and an...
5. All three types of interneurone (n = 6; 2 for each type of cell) elicited short-latency IPSPs with fast rise time (10-90%; 2.59 +/- 1.02 ms) and short duration (at half-amplitude, 15.82 +/- 5.24 ms), similar to those mediated by GABAA receptors. 6. Average amplitudes of ...
Several types of cortical GABAergic neurons acting via postsynaptic GABA(A) receptors also form electrical synapses with interneurons of the same class, suggesting that synchronization through gap junctions could be limited to homogenous interneuron populations. Neurogliaform cells elicit combined GABA(A)...
Therefore, our study provides a new approach that is generalizable to map endogenous cell membrane interactomes for G-protein-coupled receptors to decipher the molecular basis of their cell-type-specific functional regulation. This is a preview of subscription content, access via your institution ...
initiation or inhibition of electrical impulses. Such mechanisms are common forneurotransmittersthat act very rapidly. Examples include the receptors foracetylcholineand for other fast excitatory or inhibitory transmitter substances in thenervous system, such as glutamate and gamma-aminobutyric acid (GABA)....
There are more than 40 neurotransmitters in the human nervous system; some of the most important are acetylcholine, norepinephrine, dopamine, gamma-aminobutyric acid (GABA), glutamate, serotonin, and histamine. In this article, we are going to discuss the mechanism of neurotransmission, the classific...
These two populations of inhibitory, GABAergic neurons define two main output pathways of the striatum, and their unbalanced signaling is at the origin of physiopathology of several disorders of basal ganglia21. These data indicate that although RA controls differentiation of an overall population of...
they travel across the synaptic cleft to the postsynaptic membrane of the adjoining neuron, where they then bind to receptors. Receptoractivationresults in either the opening or the closing ofion channelsin the membrane of the second cell, which alters the cell’s permeability. In many instances,...
Meanwhile, drug efficacy measures the extent to which the drug can induce the physiological functions that the receptors modulate. More specifically, the binding of drugs to the receptor causes the transformation of receptors structure that are transduced into receptor-mediated signalling in the cells,...