However, drugs that target GABA_A receptor function such as the classical benzodiazepines have not been optimised to promote analgesia, are limited by side effects and are not routinely used for this purpose in humans. Compounds such as NS11394, L-838,417, HZ166 and TPA023 all bind to the...
Investigations of mice with a point mutation in a GABAA receptor subunit that eliminates the actions of drugs on certain receptors, only, have indicated that different receptor subtypes mediate distinct actions of GABAergic drugs. This conclusion was supported by experiments with newly developed ...
Woosuk Chung,Dian-Shi Wang,Shahin Khodaei,1Arsene Pinguelo,Beverley A. Orser GABAAReceptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic DrugsFront Aging Neurosci.2021; 13: 802582...
The inhibitory neurotransmitter, (-aminobutyric acid (GABA), activates a variety of receptors in all areas of the central nervous system (CNS). Until recently, two receptor subtypes were known: bicuculline-sensitive GABAA and b...
The GABAA receptor is a pluripotent drug target mediating anxiolytic, sedative, anticonvulsant, muscle relaxant and amnesic activity. These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with more selective act...
11.6). The GABAB receptor, present presynaptically, may be more important in the regulation of Ca2+ entry and has been shown to have a role in the modulation of Ca2+-dependent neurotransmitter release. GABAA receptors are more widely distributed than GABAB receptors and appear to be mainly ...
BDZ hypnotics exert their sleep-inducing action by increasing the GABA<sub class="a-plus-plus">A</sub> receptor—mediated chloride ion (Cl−) current. Possibly due to their nonspecific effect at the different subtypes of GABA<sub class="a-plus-plus">A</sub> receptors, these drugs can ...
The GABA(A) receptor gamma1-subunit in seizure prone (DBA/2) and resistant (C57BL/6) mice 来自 NCBI 喜欢 0 阅读量: 53 作者:BW Jia,FL Zhi,P Kofuji,DR Burt 摘要: [gamma]-Aminobutyric acid (GABA)A receptors are the sites of action for many antiepileptic drugs such as benzodiazepines ...
GABA(A) receptor alpha4 subunit in DBA/2J and C57BL/6J mice GABA(A) receptors are chloride channels in the brain activated by binding of gamma-aminobutyric acid (GABA). Several important classes of drugs, including ... IN Cestari,ZF Liu,W Mu,... - 《Brain Research Bulletin》 被引量...
Harrison NL (2007) Mechanisms of sleep induction by GABA(A) receptor agonists. J Clin Psychiatry . 2007 68 Suppl 5 : 6–12.Harrison NL. Mechanisms of sleep induction by GABA A receptor agonists. J Clin Psychiatry. 2007; 68 (Suppl 5):6–12. [ PubMed ]...