GABA-B receptorPostmortem studySome reports suggest cerebellar dysfunction as the basis of essential tremor (ET). Several drugs with the action of gamma-aminobutyric acid (GABA) are known to improve ET. Autopsy studies were performed on brains from nine former patients followed at the Movement ...
This influences transmitter release as well as affecting neuronal activity directly.The GABA B system can be modified by receptor ligands. This is currently exploited clinically, within the spinal cord, with the use of the GABA B agonist baclofen to treat spasticity and, to a lesser degree, ...
The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic dopamine system, which is inhibited by putative anti-craving compounds. Interestingly, different GABA(B) receptor agonists can exert similarly opposing effects on the reward pathway, but the cellular mechanisms involved...
The GABA(A) receptor gamma1-subunit in seizure prone (DBA/2) and resistant (C57BL/6) mice 来自 NCBI 喜欢 0 阅读量: 40 作者:BW Jia,FL Zhi,P Kofuji,DR Burt 摘要: [gamma]-Aminobutyric acid (GABA)A receptors are the sites of action for many antiepileptic drugs such as benzodiazepines ...
the receptor targets in astrocytes for anesthetic drugs have not been identified. GABAAreceptors, which are the major targets of general anesthetic drugs in neurons, are also expressed in astrocytes, raising the possibility tha...
Recently, focus has shifted to a new group of drugs with GABA-ergic actions mediated through various mechanisms not directly involving the GABAreceptor. These drugs include gabapentin, vigabatrin, tiagabine, lamotrigine, pregabalin and others. Although originally developed as anticonvulsants for epilepsy,...
Picrotoxin is a convulsant, which interacts with the GABA receptor complex and blocks the Cl- ionophore. A variety of hypnotic, anesthetic and anticonvulsant drugs interact with a dihydropicrotoxin binding site, and may act as Cl- ionophore agonists. Barbiturates such as pentobarbital and ...
H He,X Yue,X Ma,W Tang,C Yi,B Wang 摘要: Objective:To explore expression of GABA and GABAA receptor subunits (GABAARα1 and β2 subunits) in the anterior thalamic nucleus of rat.Methods:The mRNA of GABAARα1 and β2 subunits were examined by in situ hybridization histochemical staining...
Chemistry and Pharmacology of GABA B Receptor Ligands This chapter presents new clinical applications of the prototypic GABA(B) receptor agonist baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine, morphine, and heroin, a novel baclofen prodrug Arba... W...
摘要: strong evidence that the striatal GABAergic activity plays a cru- cial role in the GABA-OpioidsInteractions The involvement of GABAergic mechanisms in the effects of opioids has been drugsinfluence memory through a common action on the release of norepinephrine (NE) that...