Our goal here was to evaluate the pro-remyelinating potential of GABA(B)R agonist baclofen (Bac), a clinically approved drug to treat spasticity in patients with MS. We first demonstrated that Bac increases myelin protein production in lysolecithin (LPC)-treated cerebellar slices. Importantly, ...
The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by rats. Conditioned stimuli paired with drugs of abuse can acquire motivational properties, and are capable of inducing drug-seeking behavior and relapse to cocain... PD Ciano,BJ Everitt - 《Neuropsychopharmacology...
The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by rats. Conditioned stimuli paired with drugs of abuse can acquire motivational properties, and are capable of inducing drug-seeking behavior and relapse to cocain... PD Ciano,BJ Everitt - 《Neuropsychopharmacology...
BZR inverse agonist drugs bind to extrasynaptic GABAA receptors (Liang et al, 2004). Iomazenil has high affinity and selectivity for BZRs (Kd = 0.5 nM) (Johnson et al, 1990). In in vitro models, it inhibits the binding of the weak BZR inverse agonist [3H] Ro15-4513 to γ2- and ...
All categories Name GABA Agonists Accession Number DBCAT000427 Description Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). Drugs
1)GABA_A-receptor agonistGABA_A受体激动剂 英文短句/例句 1.Effects of Microinjecting GABA_A-receptor Agonist into the Tuberomamillary Nucleus on the Sleep-wakefulness Cycle in the Rat结节乳头体核微量注射GABA_A受体激动剂对大鼠睡眠—觉醒周期的影响 2.Effect of GABA and GABA_A receptor activator ...
In vivo microdialysis was used to study the effects of the locally applied GABA B receptor antagonist 2-hydroxysaclofen and GABA B receptor agonist baclofen on the basal dopamine efflux as well as on the endomorphin-1- and endomorphin-2-induced dopamine efflux in the nucleus accumbens of ...
In this case, the disruptive agent is the GABAA receptor agonist. The third line is the common paradigm nomenclature for that part of the procedure. The fourth line indicates the key assumed memory processes important to that particular phenomenon; preceding processes are assumed (eg, for ...
Picrotoxin is a convulsant, which interacts with the GABA receptor complex and blocks the Cl- ionophore. A variety of hypnotic, anesthetic and anticonvulsant drugs interact with a dihydropicrotoxin binding site, and may act as Cl- ionophore agonists. Barbiturates such as pentobarbital and ...
Agonist polyvalent GABA receptor antagonists and p 优质文献 相似文献The diversity of GABAA receptors specific effects of allosterical modulators of the GABAARs like benzodiazepines (BZs), barbiturates, steroids, some convulsants, polyvalent cations, and ... W Hevers,H Lüddens - 《Molecular Neurobio...