All categories Name GABA Agonists Accession Number DBCAT000427 Description Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). Drugs
Drugs DrugDrug Description Baclofen A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Temazepam A short-acting benzodiazepine co...
McDonald LM, Sheppard WF, Staveley SM, Sohal B, Tattersall FD, Hutson PH (2007) Gaboxadol, a selective extrasynaptic GABA A agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study. Neuropharmacology 52:844–853...
drugs may be more readily demonstrated under conditions of poor sleep quality, we investigated the influence of gaboxadol on postnap sleep.In a randomized, placebo-controlled cross-over study using a late afternoon nap model, we assessed the effects of a single oral dose of 20 mg gaboxadol on...
Muscimol as an Ionotropic GABA Receptor Agonist Graham A. R. Johnston Neurochemical Research (2014) The GABA Synapse as a Target for Antiepileptic Drugs: A Historical Overview Focused on GABA Transporters Arne Schousboe Karsten K. Madsen H. Steve White Neurochemical Research (2014) Probing th...
Picrotoxin is a convulsant, which interacts with the GABA receptor complex and blocks the Cl- ionophore. A variety of hypnotic, anesthetic and anticonvulsant drugs interact with a dihydropicrotoxin binding site, and may act as Cl- ionophore agonists. Barbiturates such as pentobarbital and ...
发明人: LANCEL Marike 被引量: 15 摘要: The invention relates to a method of treating sleep disorders in a patient in need thereof comprising the administration of a hypnotically effective amount of a non-allosteric GABAA agonist.收藏 引用 批量引用 报错 分享 文库来源 其他来源 求助全文 NON...
Tetrahydroisoxazolopyridinol (THIP), a GABA receptor agonist, γ-acetylenic-GABA(GAG) and γ-vinyl-GABA(GVG), two GABA transaminase inhibitors were given in single parenteral doses to three Cebus apella monkeys with persistent dyskinetic movements induced by earlier long-term administration of haloper...
In a within-subject design, participants received dextromethorphan (a N-methyl-D-aspartate receptor antagonist), lorazepam (LZP; a GABA<sub>A</sub> receptor agonist), scopolamine (a muscarine receptor antagonist), or placebo. The behavioral results show that detection rate decreased with increasing...
A. (1986) Separate subunits for agonist and benzodiazepine binding in the γ-aminobutyric acidA receptor oligomer.J. Biol. Chem. 261, 15,013–15,016. CAS Google Scholar Cash D. J. and Subbarao K. (1988) Different effects of pentobarbital on two γ-aminobutyrate receptors from rat brain:...