These results therefore support preliminary clinical findings and suggest that drugs with GABA(B) receptor agonist properties may aid abstinence in human drug addicts by decreasing the propensity to cue-induced drug-seeking and relapse.doi:10.1038/sj.npp.1300088Ciano, Patricia Di...
All categories Name GABA Agonists Accession Number DBCAT000427 Description Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). Drugs
Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Zolpidem A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. Drugs & Drug Targets DrugTargetType Adipiplon GABA(A) Receptor ...
The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic dopamine system, which is inhibited by putative anti-craving compounds. Interestingly, different GABA(B) receptor agonists can exert similarly opposing effects on the reward pathway, but the cellular mechanisms involved...
NEUROPHARMACOLOGY OF AGONIST AND ANTAGONIST DRUGS ACTING AT GABA-BENZODIAZEPINE-CI- CHANNEL COMPLEX. 来自 Wolters Kluwer 喜欢 0 阅读量: 29 作者: Massotti, M. 摘要: An abstract is unavailable. This article is available as a PDF only. DOI: 10.1097/00002826-198406001-00443 被引量: 1 年份:...
A variety of hypnotic, anesthetic and anticonvulsant drugs interact with a dihydropicrotoxin binding site, and may act as Cl- ionophore agonists. Barbiturates such as pentobarbital and phenobarbital enhance GABA binding in proportion to general anesthetic activity.V.Bhandari Shashikant...
In addition to drugs, changes in GABA B receptors are involved with several disorders of the nervous system. In the early 2000s, scientists discovered that a specific genetic mutation in one of the receptors makes a person far more likely to develop temporal lobe epilepsy, and are more likely...
The surge in dopamine in ventral striatal regions in response to drugs of abuse and drug-associated stimuli is a final common pathway of addiction processes. GABA B agonists exert their effects indirectly, by quieting dopaminergic afferents. The ability of the GABA B agonist, baclofen to ...
Each group of drugs has specific antagonists available for their reversal, thus allowing veterinarians to reverse one or more of the agonists depending on the desired response. This may represent a significant advantage to the use of low-dose alpha 2 agonists in combination with opioids and ...
Gamma-aminobutyric acid (GABA) agonist drugs, which ... K Soares,JJ Mcgrath,JJ Deeks - John Wiley & Sons, Ltd 被引量: 78发表: 2001年 New Approaches in the Management of Hyperkinetic Movement Disorders This review covers recent advances in a variety of dyskinesias. Introduction of new drugs...