NEUROPHARMACOLOGY OF AGONIST AND ANTAGONIST DRUGS ACTING AT GABA-BENZODIAZEPINE-CI- CHANNEL COMPLEX. 来自 Wolters Kluwer 喜欢 0 阅读量: 29 作者: Massotti, M. 摘要: An abstract is unavailable. This article is available as a PDF only. DOI: 10.1097/00002826-198406001-00443 被引量: 1 年份:...
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drugs and disease processes [38]. One example of subunit heterogeneity within the same brain structure is provided by the hippocampus. The primary subunit conformation of phasic synaptic GABAAreceptors in the dentate gyrus is α2βγ2, whereas...
Ethanol augmentation of GABAA receptor function, measured either by electrophysiological techniques or agonist-mediated Cl− flux, has been reported (Yamakura et al., 2001; Wallner et al., 2006). The similarity between the actions of ethanol and sedative drugs such as benzodiazepines and ...
McDonald LM, Sheppard WF, Staveley SM, Sohal B, Tattersall FD, Hutson PH (2007) Gaboxadol, a selective extrasynaptic GABA A agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study. Neuropharmacology 52:844–853...
BZR inverse agonist drugs bind to extrasynaptic GABAA receptors (Liang et al, 2004). Iomazenil has high affinity and selectivity for BZRs (Kd = 0.5 nM) (Johnson et al, 1990). In in vitro models, it inhibits the binding of the weak BZR inverse agonist [3H] Ro15-4513 to γ2- and ...
In addition, during withdrawal from addictive drugs, the amygdala mediates negative emotional states, such as anxiety, fear and irritability4. Avoidance of these aversive emotions enhances the incentive value of the drug, leading to sustained drug-seeking behaviors and relapse5,6,7. The amygdala is...
Hallucinogenic drugs such as LSD, psilocybin mushrooms, and DMT cause a person who has taken the drug to experience auditory, visual, tactile, or combination hallucinations. Most countries have made all hallucinogenic drugs illegal and there are many cultures where these...
Several endogenous ligands activate GABAA receptors (R) (Belelli and Lambert, 2005; Johnston, 1996); it is therefore conceivable that the transmitter released by SNcDA neurons is not GABA but a ligand that functions as a GABAAR agonist and serves as a substrate for Vmat2. Another possibility ...
5). The effects of the NMDAR antagonist dizocilpine and the GABAAR agonist phenobarbital on brain proteins appear to be age-dependent as most (see above) did not occur in mice exposed to these drugs at an age beyond the period of rapid brain growth. Download: Download high-res image (...