The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. Bolser et al. J.Pharmacol.Exp.Ther., 1995;274:1393 Characterization of the antiabsence effects of SCH 50911, a GABABreceptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. ...
Pierre Gauthier,Christian Arnaud,Gabriel Gandolfo,et al.Influence of GABA2 receptor antagonist on the sleep-waking cycle in the rat. Brain Research . 1997Gauthier P, Arnaud C, Gottesmann C. Influence of a GABA-B receptor antagonist on sleep-waking cycle in the rat. Brain Res 773: 8-14, ...
The influence of CGP 35348 (a GABA B receptor antagonist) on the sleep–waking cycle was studied in rats. The animals were injected i.p. at the beginning of the light period and the data expressed by 2-h periods and total duration (6 h). At 100 mg/kg, slow-wave sleep (SWS) was...
Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain? The interaction of the 'neurosteroid', pregnenolone-sulfate (PS), with the GABA/benzodiazepine/chloride ionophore receptor complex was investigated in rat ... Maria,Dorota,Majewska,... - 《Brain Re...
图1PVN微量注射BIC对CRS模型小鼠旷场实验的影响Figure 1Effects of microinjection of BIC into the PVN on open-field test in CRS model mice. A: movement trajectories of the 4 groups; B and C: the time and distance spent...
E. Structural model for γ-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site. Proc. Natl Acad. Sci. USA 103, 5185–5190 (2006). Article CAS PubMed PubMed Central Google Scholar Masiulis, S. et al. GABAA receptor signalling mechanisms ...
electrophysiologic properties. Focal puff application of GABA (300 μM) was applied with a Picospritzer system to evoke GABA responses. Currents were studied before and during the application of the non-competitive GABAArecept...
GABA-B2 receptor
摘要: The invention provides isolated polynucleotide molecules encoding a novel neuropeptide GABA-B receptor (designated GABA-B). These isolated polynucleotide molecules can be used to express the receptor in cells which can then be used to screen compounds for agonist and antagonist activity.收藏...
Objectives The current study was conducted to characterize the behavioral effects of a range of GHB doses in baboons ( N =4) and to evaluate whether a GABA -B receptor antagonist and a GHB receptor antagonist would block a behaviorally active dose of GHB. Methods In the first experiment, ...