GABA receptorGABA receptor antagonist2-MeTACA (trans-4-amino-2-methylbut-2-enoic acidTPMPA ((16-tetrahydropyridin-4-yl)methylphosphinic acidXenopus oocytereceptor antagonist, (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA), is eight times more potent against human recombinant ρ1...
围手术期神经认知障碍(PNDs)通常发生在麻醉和手术后的老年患者中。用全身麻醉药物治疗星形胶质细胞会刺激可溶性因子的释放,增加神经元中GABAA受体的细胞表面表达和功能。然而,这种干扰可能有助于治疗PNDs;麻醉药物在星形胶质细胞中的作用靶点...
METHODSChronic restraint stress (CRS) was used to establish a KM mouse model of anxiety and depression. (1) The mice were randomly divided into 4 groups (n=10): normal (NOR) mice+normal saline (NS) group, NOR+GAB...
The most potent GABAA receptor antagonist is the convulsant steroid derivative RU5135, being some 500 times more potent than bicuculline (Hunt and Clementsjewery, 1981). It acts as a competitive antagonist, sharing a common site of action with bicuculline. However, it lacks specificity, as it ...
1.GABA-receptor 5 1.GABA-receptor WhenGABAbindstotheGABAreceptor,thesubunitsofthereceptor"open"andthereisaninfluxofchlorideions.Thisinfluxrestorestheelectricalpotentialoftheneuronandtherebydecreasesthelikelihoodthattheneuronwilldepolarizeandrelaytheincomingsignal.Essentially,weakorirrelevantsignalsaremorelikelytobe...
The influence of CGP 35348 (a GABA B receptor antagonist) on the sleep–waking cycle was studied in rats. The animals were injected i.p. at the beginning of the light period and the data expressed by 2-h periods and total duration (6 h). At 100 mg/kg, slow-wave sleep (SWS) was...
Bath application of the GABAA receptor antagonist bicuculline, at low concentrations (1±2 mM), or picrotoxin blocked the antidromic discharges in the dorsal roots almost completely. The increase in Cl± conductance was therefore mediated by an activation of GABAA receptors. Increasing the ...
GABA AgonistsGABA AntagonistsIn the present study, we have characterized properties of steroid withdrawal using a pseudopregnant rat model. This paradigm ... SMITH,S. S. - 《Journal of Neuroscience》 被引量: 790发表: 1998年 GABA Receptor Antagonists Modulate Postmitotic Cell Migration in Slice Cu...
Microiontophoretic application of the GABA A receptor antagonist bicuculline had no effect on the suppressant effect of neuronal activity in the OFc induced ... PBF Bergqvist,J Dong,P Blier - 《Psychopharmacology》 被引量: 118发表: 1999年 A gamma-aminobutyric-acid-mediated baroreceptor input to ...
Deisz RA. The GABA(B) receptor antagonist CGP 55845A reduces presynap- tic GABA(B) actions in neocortical neurons of the rat in vitro. Neuroscience (1999) 93:1241-9. doi:10.1016/S0306-4522(99)00203-1Deisz RA. 1999. The GABA(B) receptor antagonist CGP 55845A reduces presynaptic ...