regimen of progesterone (500渭g sc, which produces physiological concentrations in plasma and the hippocampus), followed 2.5hours later by administration of saline vehicle or a regimen of bicuculline (1mg/kg, sc), a GABA A receptor antagonist, which does not produce any intrinsic effects on ...
The selective CCK receptor antagonists, L-365,260, MK-329 (0.05, 0.125 and 0.25 mg/kg) and non-selective CCK receptor antagonist, proglumide (2.5, 5, 10 and 20 mg/kg) induced antinociception only in high doses. The CCK receptor antagonists potentiated baclofen (0.75, 1.25 and 2.5 mg/...
3a). However, picrotoxin, a prototypic GABAA receptor antagonist, limited tumour growth and enhanced the cytotoxic activity of tumour-infiltrating CD8+ T cells in WT mice (Fig. 3d, e). Neither GABA nor picrotoxin treatment affected the proliferation and viability of MC38 cells in vitro (...
机译:NMDA和前肢内侧前额叶皮层中的Kainate谷氨酸能受体调节下丘脑内侧GABA_A受体阻滞引起的精心设计的防御行为和先天性恐惧诱导的抗伤害感受。 2. GABA_A receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced ...
MIDD0301 is a new lead compound designed for the oral treatment of asthma. It was developed from previously described 伪5尾3纬2 selective GABAA receptor (GABAAR) modulators. MIDD0301 showed significant relaxation of Substance P contracte... A Nieman,G Forkuo,NM Zahn,... - 《Journal of Immu...
GABA(A), D1, and D5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis. Behav. Brain Res. 103 (1), 23 - 34.Frye CA, Vongher JM (1999) GABA A , D1, and D5, but not ...
However, morphine in combination with muscimol (2 mg/kg) tends to induce higher response; the combination of the GABA receptor agonists with morphine did not show potentiation, but additive effect. The opioid receptor antagonist naloxone reduced the response induced by muscimol in nerve-ligated ...
st. effects, while a GABA(A) receptor antagonist, bicuculline (0.5, 1 and 2 mu g/rat), blocked these effects. Thus, anxiolytic and antidepressive effects of the active components of Sc. st. may be mediated by modulation of the GABAergic system....
receptor antagonist bicuculline(0.1 mg/kg)and opioid receptor antagonist nalo- xone(0.4 mg/kg)were administered intravenously,either in the presence or in the absence of 1.0% sevoflurane.Results:In rats with transected spinal cord, sevoflurane produced a profound reduction in the C response in a ...
administered GABA a -receptor antagonist picrotoxin or bicuculline on the antinociception produced by i.t. serotonin (5-HT), γ-aminobutyric acid (GABA), muscimol — the GABA a agonist or baclofen — the GABA b agonist were investigated and compared using the tail-flick assay in rats. The ...