1.Terunuma M, Pangalos MN, Moss SJ. Functional modulation of GABAB receptors by protein kinases and receptor trafficking. Adv Pharmacol. 2010;58:113-22. doi: 10.1016/S1054-3589(10)58005-0. PMID: 20655480; PMCID: PMC...
GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high physiological and therapeutic significance. In the brain, these pentameric receptors occur with diverse subunit composition, which confers highly complex pharmacology to this receptor class. An impressive range of ...
GABA RECEPTOR STRUCTURE SOLVED.GABA RECEPTOR STRUCTURE SOLVED.The article discusses a study related to discovery of crystal structure of a human gamma-aminobutyric acid GABAA receptor, conducted by structural biologists S. Miller and A. Radu Aricescu, at the University of Oxford, in England, and ...
Structure and pharmacology of vertebrate GABAA receptor subtypes Int. Rev. Neurobiol., 38 (1995), pp. 95-138 Google Scholar 29 V. Tretter, N. Ehya, K. Fuchs, W. Sieghart Stoichiometry and assembly of a recombinant GABAA receptor subtype J. Neurosci., 17 (1997), pp. 2728-2737 Google ...
However, the functional properties of GABA receptor signalling in the immature brain are significantly different from, and in some ways opposite to, those found in the adult brain. The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a ...
In the light of the interest in partial GABA-A receptor agonists as potential therapeutics, structure-activity studies of a number of analogues of 4-PIOL, a low-efficacy partial GABA-A agonist, have been performed. In this connection, a series of GABA-A ligands has been developed showing ...
1、2021/8/141第六章第六章 作用于作用于GABA受体杀虫剂受体杀虫剂l1、 GABA-receptorlGABA (-aminobutyric acid ) is a true neurotransmitter. GABAs role is that of the primary inhibitory neurotransmitter. GABA achieves this by effecting the actions of the GABA receptor, a 5 subunit ion transporter...
GABA<sub class="a-plus-plus">A</sub> receptors are assumed to have a pentameric glycoprotein structure, composed of different polypeptide subunits and, as a result, are highly heterogeneous. The GABA<sub class="a-plus-plus">A1a</sub> receptor subclass (previously termed the benzodiazepine ...
The murine GABAA receptor d subunit gene: structure and assignment to human chromosome 1 The murine chromosomal gene for the 纬-aminobutyric acid-A (GABAA) receptor 未 subunit was isolated and characterised by high-resolution mapping and DNA se... B Sommer,A Poustka,NK Spurr,... - 《Dna ...
Insect ionotropic GABA receptors are also the target of numerous insecticides and an insecticide-resistant form of a Drosophila GABA-receptor subunit has enhanced our understanding of the structure-function relationship of one aspect of pharmacology common to both insect and vertebrate GABA receptors, ...