Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Mol. Cell. 11, 1139–1150 (2003). Describes the first type IVb pilin structure for V. cholerae TcpA, which reveals a new protein fold, together ...
Their prominent display on the surfaces of many bacterial pathogens, their vital role in virulence, and their ability to elicit an immune response make Type IV pilus structures particularly relevant for study as targets for component vaccines and therapies. Structural studies of the pili and ...
type IV pilus assemblymotor ATPasesregulationsecondary messengersphage-encoded inhibitorsMany bacteria produce type IV pili (T4P), surfaced-exposed protein filaments that enable cells to interact with their environment and transition from planktonic to surface-adapted states. T4P are dynamic, undergoing ...
Polymeric filament like type IV Pilus (TFP) can transfer forces in excess of 100pN during their retraction before stalling, powering surface translocation(twitching). Single TFP level experiments have shown remarkable nonlinearity in the retraction behavior influenced by the external load as well as le...
The bacterial type IV pilus (T4P) is a versatile nanomachine that functions in pathogenesis, biofilm formation, motility, and horizontal gene transfer. T4P assembly is powered by the motor ATPase PilB which is proposed to hydrolyze ATP by a symmetrical rotary mechanism. This mechanism, which is ...
Type IV pilus-like systems are protein complexes that polymerize pilin fibres. They are critical for virulence in many bacterial pathogens. Pilin polymerization and depolymerization are powered by motor ATPases of the PilT/VirB11-like family. This family
Currently, GO:0043683 type IV pilus biogenesis is_a GO:0009297 pilus assembly. https://www.ebi.ac.uk/QuickGO-Old/GTerm?id=GO:0043683#term=ancchart However, GO:0043683 type IV pilus biogenesis is defined as "A cellular process that results in the biosynthesis of constituent macromolecules, ...
Type IV pilus structure and bacterial pathogenicity Type IV pili are remarkably strong, flexible filaments with varied roles in bacterial pathogenicity. All Gram-negative bacterial surfaces have type IV pili... L Craig,ME Pique,JA Tainer - 《Nature Reviews Microbiology》 被引量: 1012发表: 2004...
NIH 2008R01 GM Structural Microbiology of Type IV Pilus RetractionForest, Katrina T. / University of Wisconsin Madison $284,854 NIH 2005R01 GM Type IV Pili: Structural Aspects of the Assembly MechaniForest, Katrina T. / University of Wisconsin Madison $230,400 NIH 2003R01 GM Type IV Pili...
The type IV pilus is commonly found to mediate surface-associated behaviors of microorganisms, but its role on pattern formation within microbial communities is unclear. Here, we report that in a cross-feeding consortium, the type IV pilus affects the spatial intermixing of interacting populations ...