2) Immune response type 免疫应答类型3) immune response 免疫应答 1. Specific immune responses induced by a hepatitis B virus preS2S DNA vaccine in BALB/c mice.; 乙肝病毒核酸疫苗诱导BALB/c小鼠特异性免疫应答 2. Herpesvirus entry mediator:a switch in immune response and its role in anti-...
immune response. MIP-T3 interacts specifically with TRAF3, but its function in innate IFN response remains unclear. In this study, we demonstrated a negative regulatory role of MIP-T3 in type I IFN production. Overexpression of MIP-T3 inhibited RIG-I-, MDA5-, VISA-, TBK1-, and IKK«...
Type 1﹍ike immune response is found in children with respiratory syncytial virus infection regardless of clinical severityT cellbronchiolitiscytokinecellular infiltratelands). Subsequently, the slides were rinsed with PBS for 5 minutes and incubated with Link (goat anti- mouse long-chain biotinylated ...
Type I interferons (IFNs) are potent mediators of the innate immune response against viruses and cancer. There are 16 members of the type I IFN family (IFNβ, IFNɛ, IFNκ, IFNω and 12 IFNα subtypes), which signal through the same receptor — composed of the subunits IFNAR1 and I...
摘要: Mysteries of Type I IFN Response: Benefits Versus Detriments 关键词:Type I Interferons vaccine adjuvanct Viral bacterial Immune responses DOI: 10.3389/fimmu.2015.00021 被引量: 1 年份: 2015 收藏 引用 批量引用 报错 分享 全部来源 免费下载 全文购买 Semantic Scholar 掌桥科研 Semantic Scholar (...
Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. jan A,van Het Land B,et al.Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. ... AH Brandenburg,...
death during MI may disrupt DNA sequestration and liberate large quantities of self-DNA for cytosolic sensing, ultimately fueling a maladaptive IRF3- dependent innate immune response. To test this hypothesis, we studied IRF3 and the type I IFN response following permanent coronary ligation (MI) in ...
Type I interferon (IFN) is a regulatory protein involved in the innate immune response, with broad﹕pectrum antiviral activities and the ability to directly block viral replication and support the immune response to eliminate virus infection. Insufficient virus﹊nduced type I IFN production is ...
以CAR-T细胞疗法和免疫检查抑制剂(Immune checkpoint inhibitor,ICB)为代表的免疫疗法均主要用于诱导Type-1免疫反应,并且在肿瘤治疗领域取得了革命性突破。这些创新疗法通过激活患者自身的免疫系统,有效地识别并消灭癌细胞,为许多此前难以治疗的癌症患者带来了新的希望。靶向CD19的CAR-T疗法在复发/难治型B细胞急性淋巴...
免疫系统在肿瘤的发生、发展及治疗过程中扮演着关键角色。传统观点认为,Type-1免疫反应是肿瘤免疫治疗的核心力量【1,2】而削弱Type-1免疫应答的Type-2免疫反应通常被视为促进肿瘤进展的因素【3】。以CAR-T细胞疗法和免疫检查抑制剂(Immune...