We conclude the transcriptomic backgrounds, exemplified by cell‐type‐specific genes that are downstream ofxmrkeffected signaling pathways, contribute the potential to change the course of tumor development and may affect overall tumor outcomes.#A fish epidermal growth factor receptor (EGFR) oncogene ...
Compiling a comprehensive list of cancer driver genes is imperative for oncology diagnostics and drug development. While driver genes are typically discovered by analysis of tumor genomes, infrequently mutated driver genes often evade detection due to limited sample sizes. Here, we address sample size ...
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In this review, we will provide a summary of the possible mechanisms for directing the cancer phenotype of liver tumors (i.e., ICC, HCC, and cHCC-ICC) in terms of oncogenic driver genes and tumor microenvironment. Moreover, this study initially revealed the cell origin of different types ...
NGS of 68 cancer-associated genes in individual CTCs from patients with stage IV colorectal cancer found that most mutations, particularly those in driver genes, observed in the primary tumor and metastatic deposits were also present in CTCs, suggesting that the mutational spectrum of complex tumor ...
Jagged1 might therefore belong to a potential new set of cancer driver genes that could mediate different sets of tumor-stromal interactions at the primary site and metastatic sites and be selected repeatedly in several steps of cancer progression. Such genes could serve as critical therapeutic ...
Genes Chromosomes Cancer. 2007;46(1):1–9. CAS Google Scholar Van Jaarsveld MT, Helleman J, Boersma AW, Van Kuijk PF, Van Ijcken WF, Despierre E, et al. miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. Oncogene. 2013;32(36):4284–93. Google ...
Transcriptomics offers new insights into the biology of immune cells infiltrating tumors and their intercellular interactions in TIME. Changes in the transcriptome of tumor cells impact the expression of immune-related genes, triggering pathways associated with tumor immune escape, and then influencing the...
Ideally, it would be great if neoantigens can be derived from driver genes. Means that tumors won't be able to escape as they rely on such genes. However more often neoantigens occur in passengers. Certain cancer types are more susceptible to immune responce because of a higher typical mut...
W. Emerging roles of p53 and other tumour-suppressor genes in immune regulation. Nat. Rev. Immunol. 16, 741–750 (2016). Article CAS PubMed PubMed Central Google Scholar Acosta, J. C. et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat. ...