The adaptive evolution of cancer driver genes Langyu Gu Canwei Xia Guofen Yang BMC Genomics (2023) Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus Jens Luebeck Alvin Wei Tian Ng Paul S. Mischel Nature (2023) Tumor-suppressive circRHOBTB3 is excreted out of ...
The clonal evolution model of cancer was developed in the 1950s–1970s and became central to cancer biology in the twenty-first century, largely through studies of cancer genetics. Although it has proven its worth, its structure has been challenged by observations of phenotypic plasticity, non-ge...
The naked mole-rat (NMR;Heterocephalus glaber) is a mouse-sized rodent that shows no age-associated exponential increase in the risk of dying29and is remarkably cancer-resistant30,31,32, which may greatly contribute to its ability to live exceedingly longer than expected from its body size33. ...
Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify driver genes that are recurrently altered across patient cohorts. However, mapping these genes back
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when translatable to patients. The Cancer Genome Atlas (TCGA) is a compendium of ‘maps’ detailing the genetic, epigenetic and molecular
第一篇Hallmarks of Cancer,在2000 年,由瑞士Agora 转化癌症研究中心的Douglas Hanahan 教授和麻省理工学院的Robert A. Weinberg 教授共同在著名的Cell 上发表,目前已被引超3万次。 第二篇Hallmarks of Cancer:Next generation,在2011 年,还是在Cell 杂志,由两位教授对内容进行了更新,已被引超5万次。
Advanced genome sequencing has demonstrated that cancer within a single patient is a heterogeneous mixture of genetically distinct subclones that arise through branching evolution (Burrell et al., 2013, Greaves and Maley, 2012). The unique driver mutations within each subclone can impact the cancer ...
Notably, cAMP has paradoxical effects on tumorigenesis, depending on the cancer types, stages and other contexts. Thus, both the antagonists and agonists of cAMP signaling can be exploited for cancer treatment. Although the structure of PKA catalytic subunit has been solved more than 30 years ago...
Vitamin D target genes Epigenome Transcriptome Immune system Colon cancer Cancer prevention Evolution Vitamin D status Vitamin D response index 1. Introduction The molecule vitamin D3 is a derivative of 7-dehydrocholesterol, which is the last precursor to cholesterol in its biosynthesis pathway [1]....
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD in cancer have not been investiga