ancer driver genes' identification has led to the development of the paradigm of targeted anticancer therapies and, more generally, to the search for genomic biomarkers of prognosis and response to treatments.
Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic copy number alterations (CNAs) are crucial for the development of CRC. Genome-wide survey of CNAs provides opportunities for identifying cancer driver genes in an u
With the development of agents specifically designed to target these key proteins, the paradigm is changing to "personalized medicine," which consists of the individual genotyping of each patient tumor to identify driver mutations that are predictive biomarkers of the efficacy of these agents. This ...
1B, and 1D as tumor suppressers; however, unlike JARID1C, the functions of JARID1A, 1B, and 1D depend on the cellular context, which underscores their potential as cancer biomarkers and drug targets. In contrast, several studies showed that JARID1A and 1B are involved ...
144. Willis ND, Przyborski SA, Hutchison CJ, Wilson RG: Colonic and colorectal cancer stem cells: progress in the search for putative biomarkers. J Anat 2008;213 59-65. 145. Loeb LA. Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer 2011;11(6)...
In this article, based on our knowledge we have selected a set of unique biomarkers and targets that are potentially relevant to RCC but have not been comparatively reviewed in RCC. In other words, we have reviewed a set of genes and/or their proteins as potential RCC biomarkers and therapeu...
HER2-positive breast cancer Biomarkers Metastatic breast cancer Targeted therapy Introduction Human epidermal growth factor receptor-2 (HER2) is overexpressed in 15–20% of breast cancer (BC) cases, resulting in an aggressive clinical behaviour [1]. The introduction of trastuzumab has contributed to ...
“passenger” mutations, which comprise the majority of mutations identified, represent genetic events that have no direct or indirect effect on the selective growth advantage of the cell in which it occurred (Stratton et al.,2009; Vogelstein et al.,2013). Candidate epigenetic driver genes have ...
tumor cells with PNI in gastric cancer [89], however, another member of miR-200 family, miR-429 was corroborated to arrest PNI through targeting neurotrophin-3 (NT-3) in pancreatic cancer [14], suggesting the members of miR-200 family had the potential to be novel biomarkers for PNI ...
Hypoxia inducible factor 1alpha gene (HIF-1alpha) splice variants: potential prognostic biomarkers in breast cancer. BMC Med 2010; 8: 44. PubMed PubMed Central Google Scholar Iacobucci I, Lonetti A, Messa F, Cilloni D, Arruga F, Ottaviani E et al. Expression of spliced oncogenic Ikaros...