Biomarkers for breast cancer patientsKaiso, a transcriptional regulator with bimodal DNA-binding specificity, is over-expressed in breast cancer cells, and its nuclear localization is correlated with malignant and lymph node metastasis. Depleted expression of Kaiso in those cells results in a significant...
In yet a further embodiment, the patient is selected for additional treatment if the biomarker' s concentration is determined to be higher in the benign section of the tissue sample than in the cancerous section. In another embodiment, biochemical recurrence is predicted identifying patients for ...
Cancer biomarkershold out some promise for helping to improve the clinical outcomes of cancer patients. With advances in our understanding of themolecular pathogenesisof cancer and the rapid development of new technologies, thousands of potential cancer biomarkers have emerged and still only a few have...
making its accuracy as a cancer diagnostic tool very limited. Carcinoembryonic antigen (CEA) is another biomarker that is elevated in patients with colorectal, breast, lung, or pancreatic cancer. As a screening test, it can be elevated by many other factors than cancer; smoking for instance rais...
Patients older than 40 years with a first episode of unprovoked VTE are eligible, while those with major and minor transient provoking risk factors for VTE are excluded. Patients undergo standard-of-care ‘limited’ cancer screening and are followed for 12 months for the occurrence of cancer. ...
a local anesthetic with potent anticancer effects, was reported to cause melanoma cell cycle arrest by driving hnRNPA1 accumulation at the nuclear envelope and weakening hnRNPA1 protein stability [71], providing new evidence for the potential benefits of applying local anesthetics in cancer patients. ...
2: In patients who have had a previous hydatidiform mole Use of Markers as Diagnostic Aids for Cancer As discussed above with screening, limited sensitivity for small or early cancers and lack of tumor specificity preclude the use of serum markers for the primary diagnosis of cancer. In a limi...
摘要: The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk of becoming, chemoresistant.DOI: doi:WO2008115710 A3 ...
The result was surprising because it suggests, contrary to conventional wisdom, that isoform ratios provide a more robust molecular signature of cancer patients than overall gene abundance, said Xing, director of UCLA's bioinformatics doctoral program and a member of the UCLA Institute for Quantitative...
However, the breast cancer segment is anticipated to grow at the fastest CAGR of 16.70% during the forecast period. This can be attributed to the increase in prevalence of breast cancer due to the adoption of unhealthy lifestyle, genetic profile of patients, growth in female geriatric population...