Driver and Passenger Mutations in Cancer[J] . Julia R. Pon,Marco A. Marra.Annual Review of Pathology: Mechanisms of Disease . 2015Pon JR, Marra MA. Driver and passenger mutations in cancer. Annu Rev Pathol 2015; 10: 25-50.Driver and Passenger Mutation in Cancer. Mirny L. . 2015...
Tug-of-warbetweendriverandpassengermutationsincancerandotheradaptiveprocessesChristopherD.McFarlanda,LeonidA.Mirnya,b,c,1,andKirillS.Korolevb,d,1aGraduatePrograminBiophysics,HarvardUniversity,Boston,MA02115;bDepartmentofPhysicsandcInstituteforMedicalEngineeringandScience,MassachusettsInstituteofTechnology,Cambridge,...
Rather a pool of “Ca2 + genes” might be considered to act as one potential cancer driver. This article is part of a Special Issue entitled: Calcium and Cell Fate . Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen....
The fact that the somatic insertions reported by Lee and colleagues were skewed toward genes that are commonly downregulated or mutated in the tumors that they studied suggests that L1 insertions may contribute to cancer formation. In order to determine whether L1 actually...
Table S2. Correlation between Somatic Impact Burden and Tumor Prevalence (Quantified by Mean VAF), Related to Figure 2 Table S3. p Values for Additive Variance Analyses Performed on All Samples as well as Samples Lacking Any Drivers, Related to Figure 5 Table S4 List of Weak Driver Genes/Elem...
Geng J, Song Q, Tang X, Liang X, Fan H, Peng H, et al. Co-occurrence of driver and passenger bacteria in human colorectal cancer. Gut Pathog 2014; 6:26.Geng J, Song Q, Tang X, et al. Co-occurrence of driver and passenger bacteria in human colorectal cancer. Gut Pathog 2014;6...
Background We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes between the human and other mammals. As an initial test of this strategy, we conducted ...
Lastly, we review recent efforts aimed at developing novel splicing-targeted cancer therapies, which employ oligonucleotide-based approaches or chemical modulators of alternative splicing that elicit an impact on brain tumor biology.Progress in Artificial Intelligence...
The mutational profiles of primary colorectal cancers (CRCs) and corresponding ovarian metastases were compared. Using a custom-made next generation sequencing panel, 115 cancer-driving genes were analyzed in a cohort of 26 primary CRCs and 30 matching ovarian metastases (four with bilateral metastases...
For a few genes, CRS under called driver mutations (ie VHL in renal cancer) likely due to reduced power with small sample numbers. Importantly, CRS is able to assign driver status to individual missense mutations. Comparison with informatic analyses (PMIDs 28115009, 29247016, 30365005, 31034466)...