Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancerImmune responseIntercellular communicationMicrovesiclesExtracellular vesicles (EVs) are a heterogeneous collection of membrane-bound vesicles released by cells that contain bioactive cargoes including...
Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy Int. J. Nanomedicine, 16 (2021), pp. 5395-5409, 10.2147/ijn.S313912 View in ScopusGoogle Scholar 14 C. Xu, D. Ju, X. Zhang Cell Membrane-Derived Vesicle: A Novel Vehicle for Cancer Immunotherapy Front. Immu...
Tumor-derived extracellular vesicles (EVs) are key immune regulators of the tumor microenvironment. They reshape the immune microenvironment and prevent antitumor immune responses via their immunosuppressive cargo, thereby determining cancer responsiveness to treatment. In the immune microenvironment of melanoma...
The application of tumor-derived exosomes (TDEs). The application of tumor-derived exosomes (TDEs) is mainly divided into two kinds: as a biomarker for diagnosis and participating in treatment. Starting from the diagnostic biomarkers, the biomarkers related to diagnosis or prognosis should be determi...
Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated secretory phenotype (SASP). Extracellular vesic
et al. Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival. Sci. Rep. 7, 11518 (2017). Okoye, I. S. et al. MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Immunity 41, 89–103 (...
Accumulating data indicates that tumor-derived extracellular vesicles (EVs) are responsible for tumor-promoting effects. However, if tumor EVs also prepare the tumor-bearing organ for subsequent tumor growth and if this effect is different in low and hig
Because tumor-derived extracellular vesicles (tdEVs) are expected to be present in a higher concentration than CTCs, measuring tdEVs is expected to increase the percentage of patients from which informative information can be obtained. This thesis reveals the challenges to detect tdEVs in blood and...
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence Introduction Extracellular vesicles (EVs) produced by tumors, also called tumor-derived exosomes (TEX), have been implicated in inducing immune cell suppression in vitro and in...
Basics and applications of tumor-derived extracellular vesicles Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering th... ...