We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumour EVP secretion via depletion of Ra
2. Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of systemically affected livers in mouse models and in patients with extrahepatic metastasis. We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic re...
1. Extracellular vesicles Extracellular vesicles (EVs) are lipid bilayer delimited nano- to micro- sized particles released by most, if not all, cell types [1]. Initially regarded simply as a means for cells to release debris, we now know that these anucleate, thus non-replicating, entities ...
Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature 618, 374–382 (2023). Article CAS PubMed PubMed Central Google Scholar Austin, J. & Marks, D. Hormonal regulators of appetite. Int. J. Pediatr. Endocrinol. 2009, 141753 (2009). Article PubMed Google ...
Nanofibers are perfect for CTC capture because of their high surface-to-volume ratios and flexibility, which make them look like the extracellular matrix. Efficient CTC harvesting from blood samples is made possible by incorporating MnO2 and PLGA into microfluidic chips(6). To get the most out of...
However, the communication between hypoxic cells and normoxic cells during the transfer of radiation resistance remains unclear. Exosomes and extracellular vesicles (EVs) are small particles of 30–200 nm in diameter that are encapsulated by dual membranes. EVs encapsulate various intercellular ...
The resulting exosome pellet was labelled with a lipophilic (green) fluorescent dye and co-cultured with the reciprocal target cell (MRC5 or DLD-1). The cells were then washed thoroughly to remove all extracellular particles and visualised by fluorescence microscopy. Cell lysate was analysed by ...
The secondary and tertiary particles of neutrophils contain many matrix-degrading enzymes. Neutrophil-sourced MMP-8 can degrade collagen I and III, MMP-9 can cleave collagen IV [78], and MMP-25 can digest collagen IV and FN [79]. During wound healing, degradation of the ECM occurs to facil...
Cancer is a major cause of high morbidity and mortality worldwide. Several environmental, genetic and lifestyle factors are associated with the development of cancer in humans and result in suboptimal treatment. The human microbiota has been implicated i
Pancreatic ductal adenocarcinoma (PDAC) exhibits a high frequency of neural invasion (NI). Schwann cells (SCs) have been shown to be reprogrammed to facilitate cancer cell migration and invasion into nerves. Since extracellular vesicles (EVs) affect the