based on differential ultracentrifugation (dUC), to isolate extracellular vesicles and particles (specifically exomeres) (EVPs) from various human and murine sources, including cell lines, surgically resected tumors and adjacent tissues, and bodily fluids, such as blood, lymphatic fluid, and bile. Th...
Moreover, we deconvoluted the heterogeneity of extracellular nanoparticles, defining three distinct subpopulations, small exosomes (Exo-S), large exosomes (Exo-L), and exomeres (Zhang and Lyden, 2019) that we collectively refer to as extracellular vesicles and particles (EVPs). Mounting evidence ...
Profiling and promise of supermeres. Nat. Cell Biol. 23, 1217–1219 (2021). Article CAS PubMed PubMed Central Google Scholar Lucotti, S., Kenific, C. M., Zhang, H. & Lyden, D. Extracellular vesicles and particles impact the systemic landscape of cancer. EMBO J. 41, e109288 (...
These particles are known as extracellular vesicles (EVs) and include species of exosomes and shed microvesicles. EVs carry molecules such as oncoproteins and oncopeptides, RNA species (for example, microRNAs, mRNAs, and long non-coding RNAs), lipids, and DNA fragments from donor to recipient ...
1.Tumour extracellular vesicles and particles induce liver metabolic dysfunction. 肿瘤细胞外囊泡和颗粒诱导肝脏代谢功能障碍。 [Nature] PMID: 37225988 摘要:癌症改变了多个器官的功能,超出了转移所针对的器官。在这里,我们表明炎症、脂肪肝和代谢失调...
Extracellular Vesicles in Liver Pathobiology: Small Particles With Big Impact Abbreviations: ALIX, apoptosis-linked gene-2 interacting protein X; CCA, cholangiocarcinoma; CD, cluster of differentiation; CTGF, connective tissue growth factor; CXCL10, chemokine (C-X-C motif) ligand 10; ESCRT, endosomal...
Extracellular Vesicles and Circulating Nucleic Acids, Editor-in-Chief Yoke Peng Loh, is a peer-reviewed journal dedicated to in-depth research into the molecular and cellular biology, biogenesis, and origins of extracellular vesicles or exosomes and circ
Extracellular Vesicles and Circulating Nucleic Acids, Editor-in-Chief Yoke Peng Loh, is a peer-reviewed journal dedicated to in-depth research into the molecular and cellular biology, biogenesis, and origins of extracellular vesicles or exosomes and circ
Extracellular vesicles (EVs) have various advantageous properties, including a small size, high biocompatibility, efficient cargo loading, and precise cell targeting ability, making them promising tools for therapeutic development. EVs have been increasingly explored for applications like drug delivery. Howev...
Malkin EZ, Bratman SV. Bioactive DNA from extracellular vesicles and particles. Cell Death Dis. 2020.https://doi.org/10.1038/s41419-020-02803-4. ArticlePubMedPubMed CentralGoogle Scholar ArticleCAS Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, et al. Exosomes maintain ...