秋分,学习细胞外囊泡(extracellular vesicles)在免疫系统中的作用,在先天免疫和适应性免疫基本过程中的作用,包括炎症、抗原呈递以及B细胞和T细胞的发育和活化。 1、细胞外囊泡的异质性Heterogeneity of extracellular vesicles. 细胞外囊泡Extracellular...
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellu...
Immunoregulatory properties of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique immunoregulatory capacity and secrete large amounts of EVs. Recent findings suggest that priming MSCs with inflammatory stimuli is an effective ...
10.Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption. 来自鼠乳杆菌的细胞外囊泡减轻脱氧雪腐镰刀菌烯醇诱导的肠道屏障破坏的新机制。 [Environ Int] PMID: 38408410 摘要:脱氧雪腐镰刀菌烯醇(DON)是一种常见的环境污染物...
Although the protective effect of M2‐like macrophages (M2φ) and their extracellular vesicles (EVs) has been well‐documented in other inflammatory diseases, the role of M2φ‐derived EVs (M2φ‐EVs) in the pathogenesis of ALI/ARDS remains poorly understood. The present study utilised a mouse...
Cells have been increasingly known to release extracellular vesicles (EVs) to the extracellular environment under physiological and pathological conditions. A plethora of studies have revealed that EVs contain cell-derived biomolecules and are found in circulation, thereby implicating them in molecular traff...
Small extracellular vesicles derived from PD-L1-modified mesenchymal stem cell promote Tregs differentiation and prolong allograft survival We aimed to explore whether programmed cell death protein-1 ligand (PD-L1) modification on small extracellular vesicles (sEVs) could promote T regulatory c... Q ...
Yi Wen#, Qin Fu#, Ashley Soliwoda, Sheng Zhang, Mingfeng Zheng, Wenjun Mao*, Yuan Wan*.Cell-derived nanovesicles prepared by membrane extrusion are good substitutes for natural extracellular vesicles.Extracellular Vesicle,Volume...
Extracellular vesicles (EVs) derived from human adipose-derived stem cells (hADSCs) possess the proangiogenic potential for ischaemic diseases. Thus, our study aimed to evaluate the therapeutic effects of hADSC-EVs on fat grafting and explore the mechani
Bystander T-cells support clonal T-cell activation by controlling the release of dendritic cell-derived immune-stimulatory extracellular vesicles. Front. Immunol. 10, 448 (2019). Article CAS PubMed PubMed Central Google Scholar Torralba, D. et al. Priming of dendritic cells by DNA-containing ...