Extracellular vesicles (EVs) are membrane‐enclosed nanovesicles secreted by cells into the extracellular space and contain functional biomolecules, e.g. signaling receptors, bioactive lipids, nucleic acids, and proteins, which can serve as biomarkers. Neurons and glial cells secrete EVs, contributing ...
We demonstrated that mice subjected to TBI release significant amounts of brain-derived extracellular vesicles (BDEVs) into the circulation, where these BDEVs induce a systemic hypercoagulable state that rapidly develops into consumptive coagulopathy [53]. Key molecules involved in this BDEV-induced s...
The current findings demonstrated increased presence of L1CAM neuronal-derived EVs both in the brain and serum of HIV-1 Tg rats.doi:10.1080/20013078.2019.1703249Raghubendra Singh DagurKe LiaoSusmita SilFang NiuShilpa BuchJohn Wiley & Sons, LtdJournal of Extracellular Vesicles...
Engineered cell-derived extracellular vesicles (EVs) such as exosomes and microvesicles hold immense potential as safe and efficient drug carriers due to their lower immunogenicity and inherent homing capabilities to target cells. In addition to innate vesicular cargo such as lipids, proteins, and nucle...
Herein, brain endothelial cell-derived extracellular vesicles (bEVs) were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the BBB. To enhance PDT efficacy, the photosensitizer chlorin e6 (Ce6) was linked to mitochondria-targeting triphenylphosphonium (TPP) and...
Heikki Kyykallio ……& Pia R-M Siljander. (2022) A quick pipeline for the isolation of 3D cell culture-derived extracellular vesicles.Journal of Extracellular Vesicles. Roberto Frigerio ……& Marina Cretich. (2022) Comparing digital detection platforms in high sensitivity immune-phenotyping of extr...
Proteins implicated in neurodegenerative conditions such as Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) have been identified in bodily fluids encased in extracellular vesicles called exosomes. Whether exosomes found in DLB patients can transmit pathology is not clear. In this study,...
Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response Article 12 August 2021 Code availability The R code used for the analysis in this manuscript is available upon request. Data availability The sequencing data is...
Comparison of Extracellular Vesicles from Induced Pluripotent Stem Cell-Derived Brain Cells Exosomes excreted into the circulatory system can cross the blood鈥揵rain barrier and carry a cell type-specific set of molecules. Thus, exosomes are a ... G Xavier,A Navarrete Santos,C Hartmann,... - ...
de Vrij J, Maas S, Kwappenberg K et al (2015) Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. Int J Cancer 137:1630–1642 ArticlePubMed Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA (2005) Tissue-factor-bearing microvesicles arise from lipid rafts ...