Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellu...
Engineered cell-derived extracellular vesicles (EVs) such as exosomes and microvesicles hold immense potential as safe and efficient drug carriers due to their lower immunogenicity and inherent homing capabilities to target cells. In addition to innate vesicular cargo such as lipids, proteins, and ...
56Altmetric Metrics Abstract Small extracellular vesicles (EVs) are signalling messengers that regulate inter-tissue communication through delivery of their molecular cargo. Here, we show that liver-derived EVs are acute regulators of whole-body glycaemic control in mice. Liver EV secretion into the ci...
Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key paracrine component of stem cell potency, overcome the drawbacks of stem cell applications...
Mesenchymal stem cell-derived extracellular vesicles mRNA: Messenger RNA miRNA: Micro RNA MVBs: Multivesicular bodies S1P: Sphingosine-1-phosphate ESCRT: Endosomal sorting complex required for transport Alix: ALG-2-interactingproteinX HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate ...
Hence, MSC-derived extracellular vesicles may be used as an alternative MSC-based therapy in regenerative medicine. In this review we discuss MSC-derived extracellular vesicles and their therapeutic potential in various diseases. 展开 关键词: Extracellular vesicles, Mesenchymal stem cells, Regenerative ...
摘要:内质网到核信号转导1(ERN1,又称IRE1A)是非酒精性脂肪性肝炎(NASH)患者肝脏中激活的未折叠蛋白反应的感受器。IRE1A活化后,肝细胞释放富含神经酰胺的炎性细胞外小泡(EVS)。我们研究了抑制IRE1A对饮食性脂肪性肝炎小鼠炎症EVS释放的影响。C57BL/6J小鼠和Ire1a肝细胞特异性干扰(IRE1HEP)小鼠被喂以高脂肪、...
Adipocytes Extracellular vesicles HIF-1α Abbreviations TNBC Triple-negative Breast Cancer EVs Extracellular Vesicles MSCs Mesenchymal Stem Cells HIF-1α Hypoxia-Inducible Factor-1α TEM Transmission Electron Microscopy NTA Nanoparticle Tracking Analysis MMP-2 and MMP-9 Metalloproteinase 2 and 9 MFE Mammosp...
The escalating threat of bone-related diseases poses a significant challenge to human health. Mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs), as inherent cell-secreted natural products, have emerged as promising treatments for bone-related diseases. Leveraging outstanding features ...
MSC-derived extracellular vesicles Although MSCs derive from a variety of sources, they can all be adherent in culture and differentiated into a variety of cell types with specific surface markers [54]. With the need for clinical treatment with MSCs, the Mesenchymal and Tissue Stem Cell Committee...