Immunohistochemical staining revealed the tumor cells were positive for CD117, vimentin, CD99, Bcl-2 and EMA. While Keratin, Dog-1, CD34, α-inhibin and calretinin et al. were negative. The patient is survival now 4.5 years after adrenalectomy without any therapy, but there has been a ...
2). The latter is composed of lymphocytes, plasma cells, giant cells and particular large histiocytoid cells resembling ganglion cells (Fig. 3). On resection specimen, tumor cells were positive for ALK, Smooth Muscle Actin and negative for Cytokeratin, MDM2, CD117, Desmin along with ...
Immunohistochemistry showed tumor cells to be posi- tive for CD 117/c-kit, and slightly positive for MS-actin and SM-actin. The tumor cells were negative for CD 34, S 100, and only focally positive for vimentin. A final conclusion of an in part cystic degenerated GIST was made of the...
The tumor was composed mainly of epithelioid cells. Immunohistochemically, the tumor cells were positive for Vim, CD117, PDGFR, while negative for SDHB. Mutational analysis showed a synonymous mutation for SDHB and wild-type for KIT and PDGFRA. Two months after surgery, metastases were found and...
cells with focal areas showing perinuclear vacuoles(F ig.2A and B). Foci of necrosis consistent with treatment effect were also identi- fied within the tumor(F ig.2C).Immunostains for CD117(F ig.2D) and DOG1were diffusely positive within the tumor,supporting the final diagnosis of pr...
CD5 is a characteristic surface marker of malignant T cells that is extremely important for cell survival and is only expressed in a subset of immune system cells in normal tissues [58,59] (Fig.2). The investigators created a CD5 CAR-T cell that could secrete IL-15 with the enhanced an...
Immunohistochemistry, YST tumor cells were positive for AFP, GPC-3, SALL4, CD117 and PLAP, and negative for D2-40, CD30, EMA, HCG and OCT3/4. The proliferation index of Ki-67 was 80% (Fig. 2G-I). The tumor had invaded the bilateral seminal vesicles. One lymph node of the ...
Using the cell surface markers Epithelial Specific Antigen (ESA+), CD44+, and CD24−, populations of stem-cell-like cells in breast cancer can be identified [11,102]. It is shown that in the xenograft mouse model, as few as 200 cells of these cells can form tumors [11]. In additio...
Immunohistochemically, the tumor cells were positive for Ckit (CD117) Dog1, Vimentin and negative for CD34, Desmin, Chromogranin, and S100. According to TMN staging, the pathological stage of the excised tumor is PT3 Nx Mn/a, stage IIIB. These findings indicate a high risk of recurrence ...
Immunohistochemistry was positive for synaptophysin, chromogranin, CD117 and CK with high Ki 67, proliferative Index of >90% consistent with high grade neuroendocrine tumor. The tumor cells were negative for CD-45 (Fig. 8). Subsequently, the patient underwent 3 cycles of adjuvant chemotherapy inclu...