答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
Easily and efficiently isolate highly purified mouse myeloid-derived suppressor cells (MDSCs) (CD11b+Gr1+) from mouse splenocytes, bone marrow, or peripheral blood samples by immunomagnetic negative selection, with the EasySep™ Mouse MDSC (CD11b+Gr1+) Isolation Kit. Widely used in published ...
Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor cells. We then sorted the Gr1(hi) and Gr1(int) populations from M. tuberculosis infected NOS-/- mice and placed the sorted both Gr1(int) populations at different ratios ...
CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice. Hepatology 2012; 56: 1902-1912 [PMID: 22544759 DOI: 10.1002/hep.25817]Suh, Y. G. et al. CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice. ...
Conclusions:CD11b+Gr1+ myeloid cells promote neurite growth in TG cells. These cells infiltrate the cornea after nerve transection surgery and interact with the regenerating nerves; thus they may promote reinnervation by their neurotrophic action. One mechanism by which these cells promote neurite ...
制备坏死肿瘤细胞释放物(moleculesfromnecrotictumorcells,NTC-Ms) 模拟肿 瘤微环境进行研究,证实了在肿瘤微环境中巨噬细胞具有促进肿瘤生长的生 物学 功能。 + 通过进一步分析肿瘤组织单个细胞、不同肿瘤小鼠骨髓来源的F4/80 5华中科技大学同济医学院博士研究生学位论文 ...
We were led to conclude that WBI can significantly decrease the accumulation of CD11b+Gr-1+cells in the spleen, reduce the infiltration of Gr1+CD11b+ cells in the tumor and finally delay the tumor re-growth after irradiation. Elimination of CD11b+ myelomonocytic cells-derived neovasculature by...
CDlib+GR1+MDSCSsortedfrom young miceandelderlymice。ResultsCompared with young MDSCs.elderlvMDSCscould evidentlysuppresstheproliferationofTcells(t一8.67,P<0.001), andthisfunctioncouldbereversedbytrans—wellCO—culture(￡一6.93,P%0.001).Theresultsofreal— ...
CD11b+ Gr1dim cells were transferred to ZyA-treated SKG mice.MDSCs, Th17 cells, and group 1 and 3 innate lymphoid cells (ILC1s and ILC3s) were increased in the lungs; the proportion of these cells varied with ILD severity. In this process, we found that a unique cell population, CD...
Gr-1(+) cells could be found on the edges of necrotic lung lesions in NOS2-/-, RAG-/-, and C3HeB/FeJ, but were absent in wild-type mice. Both populations of Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor ...