答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
浙江大学博士学位论文CD11b<'+>Gr-1<'+>髓系抑制性细胞通过膜结合型TGFβ抑制NK细胞杀伤活性的研究姓名:李和权申请学位级别:博士专业:肿瘤学指导教师:曹雪涛20070501
华中科技大学硕士学位论文Gr-1<'+>CD11b<'+>髓样前体细胞在小鼠哮喘相关炎症中作用的初步研究姓名:王晓梅申请学位级别:硕士专业:生物化学与分子生物学指导教师:黄波;冯作化009056
肿瘤微环境中F4/80CD11bGr-1 单核细胞活化机制的研究 博士研究生:刘颜颜 指导教师:**化教授中文摘要既往认为巨噬细胞能分泌多种细胞因子,通 过抑制肿瘤细胞生长及促进T细 胞凋亡等机制产生肿瘤抑制作用。但近年来研究发现肿瘤微环境中的巨噬细 胞虽
There was no evidence for involvement of an adaptive immune response in the prometastatic effects of CD11b/Gr1cells. Additionally, an analogous myeloid subset was found in liver metastases of some colorectal cancer patients. : Collectively, our findings highlight the importance of myeloid cells—in ...
《与Gr1+CD11b+髓系抑制细胞分化和功能有关的微小RNA研究》是依托南开大学，由杨荣存担任项目负责人的面上项目。中文摘要 Gr1+CD11b+髓系抑制细胞可由肿瘤与一些感染因素如病毒、细菌和寄生虫等诱导而大量产生,在产生免疫抑制、引导免疫逃逸过程中发挥着重要作用。研究免疫髓系抑制性细胞的关键在于搞清免疫髓...
Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor cells. We then sorted the Gr1(hi) and Gr1(int) populations from M. tuberculosis infected NOS-/- mice and placed the sorted both Gr1(int) populations at different ratios ...
Easily and efficiently isolate highly purified mouse myeloid-derived suppressor cells (MDSCs) (CD11b+Gr1+) from mouse splenocytes, bone marrow, or peripheral blood samples by immunomagnetic negative selection, with the EasySep™ Mouse MDSC (CD11b+Gr1+) Isolation Kit. Widely used in published ...
The CD11b+ Gr1dim cells have never described previously and termed CD11b+ Gr1dim tolerogenic dendritic cell-like cells (CD11b+ Gr1dim tolDC-LCs). Th17 cells, ILC1s and ILC3s in the inflamed lung produced GM-CSF, which may expand CD11b+ Gr1dim tolDC-LCs in vivo. Furthermore, adoptive...