As tumor PD-L1 provides signals to anti-tumor PD-1^(+)T cells that blunt their functions,伪PD-1 and伪PD-L1 antibodies have been developed as anti-cancer immunotherapies based on interrupting this signaling axis.However,tumor cell-intrinsic PD-L1 signals also regulate immune-independent tumor ...
OPEN Citation: Signal Transduction and Targeted Therapy (2016) 1, 16030; doi:10.1038/sigtrans.2016.30 www.nature.com/sigtrans ARTICLE Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer Harshita B Gupta1, Curtis A Clark2, Bin Yuan3,...
抑制外泌体PD-L1可诱导机体的抗肿瘤免疫和记忆功能 肿瘤细胞表面的PD-L1蛋白,通过与T细胞表面的PD-1受体结合,抑制了T细胞的活性。PD-L1抑制剂通过激活抗肿瘤免疫反应从而使一部分肿瘤患者达到一个持久的缓解。在此,我们发现了一个PD-L1活性的替代机制,涉及到肿瘤来源外泌体的分泌。即使在抗PD-L1抗体的模型中,去...
PD-L1 was exclusively expressed on either TC or IC. Transcriptome analysis demonstrated that IC3 expressed higher levels of the effector T cell markers than TC3, suggesting that PD-L1 expression is regulated via an adaptive IFN纬-mediated mechanism. High PD-L1 expression on IC, but not TC, ...
Thus, PD-L1 might play an important role in tumor immune evasion. This review discusses the currently available data concerning negative T-cell regulation via PD-1, the blockade of PD-L1/PD-1 interactions, and the implications for adoptive T-cell therapies. 展开 关键词: Immune evasion ...
and TRAPs isolated from these samples could also polarize monocytes to an M2-like phenotype with increased expression of PD-L1, CD163 and IL-10, decreased expression of HLA-DR, and T cell-suppressive function.These findings suggest the TRAPs-PD-L1 axis as a major driver of immunosuppression ...
Monitoring PD-L1 positive circulating tumor cells in non-small cell lung cancer patients treated with the PD-1 inhibitor Nivolumab. Sci. Rep. 2016; 6: 31726. 21 Mazel M, Jacot W, Pantel K et al. Frequent expression of PD-L1 ... T Kato - 《International Journal of Urology》 被引量:...
In hormonal mice, the drug blocked tumor cell metabolism while reducing hypoxia, acidosis and nutrient depletion, thereby promoting natural anti-tumour T-cell responses. The study also showed that the combination of JHU083 with programmed cell death protein 1 (PD-1) was effective in improving ...
PD-L1 is preferentially expressed on CD44+ tumor-initiating cells in head and neck squamous cell carcinoma Sunwoo, "PD-L1 is preferentially expressed on CD44+ tumor-initiating cells in head and neck squamous cell carcinoma," Journal for Immunotherapy of Cancer,... Y Lee,J Sunwoo - 《Journal ...
Blood samples were then obtained from pts with advanced non-small cell lung (NSCLC), prostate, ovarian, rectal and breast cancers for CTC isolation on FX and CS. CTCs captured on FX were assessed with 5-color immunofluorescence (IF) (CK, CD45, DAPI, PD-L1, as well as TTF-1 [lung ...