Transient receptor potential vanilloid channel (TRPV1) is a thermo-sensitive, polymodal gated and permeable to cations such as Ca2+. It has been reported that TRPV1 expression increases during T cell activation. However, the possible involvement of TRPV1 during immunosuppression of T cells has ...
Moreover, microglia-specific deficiency of TRPV1 gene accelerated glial inflammation, T cell response and associated neurodegeneration in an APOE4 -related tauopathy mouse model.The findings provide new perspectives for the treatment of APOE4 -dependent neurodegeneration including AD. 展开 ...
多种过敏因素(如尘螨、蟑螂残留物、动物毛 发、霉菌、花粉) 和非过敏因素(如感染、香烟烟雾、冷空气、运动等)均可触发T型辅助细胞2 型(T helper cell type‑2, Th2)免疫应答反应,导致慢性气道炎症。气道中Th2细胞水平 升高,释放包括白介素(Interleukin)4(IL‑4)、 IL‑13、IL‑5和IL‑13在内的...
The specific biological function of transient receptor potential vanilloid 1 (TRPV1) in pathogenesis of lung adenocarcinoma (LUAD) remains unclear. In this study, TRPV1 expression in tumor tissues, primary cells and cell lines of LUAD, as well as the mec
Using a specific antibody for immunostaining, TRPV1 immunoreactivity in the urothelium was quantified by image analysis. TRPV1 immunoreactivity was observed in basal and apical urothelial cells. Basal cell layer TRPV1 immunoreactivity was significantly increased in NDO compared with control bladders (...
Intrathecal administration of the TRPV1 siRNA not only attenuated behavioural hyperalgesia but also reduced the expression of TRPV1 and CAMKII, as well as ERK2 phosphorylation. Based on these results, silencing of the TRPV1 gene in the spinal cord attenuates the maintenance of neuropathic pain ...
T R P V1的概述 TRPV1是瞬时受体电位阳离子通道亚家族成 员中首次被发现和克隆的受体，Caterina等[5]在 1997年成功克隆了可以被辣椒素激活的TRPV1受 体，因此，该受体也被称为辣椒素受体。TRPV1具 有S1 -S6六个跨膜结构，它包括838个氨基酸，N 末端和C末端都在细胞膜内，而且有三个重复的锚 蛋白结合...
The inhibition of TRPV1, pharmacological suppression of cPLA2, or blockade of lipid peroxidation could prevent HS-induced ferroptosis and improve ALI. These results suggest that cPLA2 targeting might be a novel therapeutic approach to limit cell death and prevent HS-induced ALI. 2. Materials and...
多种过敏因素(如尘螨、蟑螂残留物、动物毛发、霉菌、花粉) 和非过敏因素(如感染、香烟烟雾、冷空气、运动等)均可触发t型辅助细胞2型(t helper cell type-2, th2)免疫应答反应,导致慢性气道炎症。气道中th2细胞水平升高,释放包括白介素(interleukin)4(il-4)、 il-13、il-5和il-13在内的细胞因子,促进肥大...
DNase (0.5 mg/ml; Sigma, St Louis, Missouri, USA) was used during repeated trituration to make a single cell suspension. Isolated cells were plated onto acid-cleaned glass coverslips. Under the fluorescence and bright-field microscope (Olympus IX71, Japan), DiI-labeled neurons were ...