近日,来自美国哈佛医学院的Isaac M. Chiu团队于Science上在线发表题为A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut的文章,利用交叉的化学遗传学方法来确定不同的神经元是如何调节肠...
近日,匹兹堡大学(University of Pittsburgh)Daniel H. Kaplan团队在Cell上发表文章Cutaneous TRPV1+Neurons Trigger Protective Innate Type 17 Anticipatory Immunity,揭示了皮肤下神经元细胞可以触发免疫细胞17型免疫反应。 研究人员人员在小鼠...
[22] GOUIN O, L'HERONDELLE K, LEBONVALLET N,et al. TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization[J]. Protein Cell,2017,8(9):644-661. [23] 黄翠萍,杨和平,徐永健.p38蛋白激酶对支气管哮喘大鼠Th...
Transient receptor potential vanilloid channel (TRPV1) is a thermo-sensitive, polymodal gated and permeable to cations such as Ca2+. It has been reported that TRPV1 expression increases during T cell activation. However, the possible involvement of TRPV1 during immunosuppression of T cells has ...
在同期Cell上,来自哈佛大学的Issac Chiu实验室团队也发表了相关研究论文Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection,得出了相似的结论(详见今日BioArt的单独推送),以上研究丰富了感受神经元TRPV1+ 痛觉感受器在肠道免疫中的调控功能,为...
53l-543. and sensationinmice the receptor[J】. nociceptionpain lackingcapsaicin 13. Science2000;288:306·3 24.Christoph,T.,Bahrenberg,G,De ofTRPV1 loss—of-function in Kurreck,J.Investigation phenotypes knockout CellNeurosci shRNA and transgenicexpressing mice[J].Mol 2008;37:579-589. their...
多种过敏因素(如尘螨、蟑螂残留物、动物毛 发、霉菌、花粉) 和非过敏因素(如感染、香烟烟雾、冷空气、运动等)均可触发T型辅助细胞2 型(T helper cell type‑2, Th2)免疫应答反应,导致慢性气道炎症。气道中Th2细胞水平 升高,释放包括白介素(Interleukin)4(IL‑4)、 IL‑13、IL‑5和IL‑13在内的...
在同期Cell上,来自哈佛大学的Issac Chiu实验室团队也发表了相关研究论文Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection,得出了相似的结论(详见今日BioArt的单独推送),以上研究丰富了感受神经元TRPV1+ 痛觉感受器在肠道免疫中的调控功能,为研究神经...
View PDF Download full issue Search ScienceDirect Outline Summary Introduction Results Discussion Experimental Procedures Acknowledgments Supplemental Information ReferencesShow full outline Figures (4) Extras (1) Document S1. Figures S1–S5, Tables S1 and S2, and Supplemental Experimental Procedures...
and TRPV1 knockout mice immunostained with the neuronal marker Neurotrace, and DAPI, to mark cell nuclei, we failed to detect any obvious structural alteration in the brain of TRPV1 knockout mice; cortical layers I–VI, DG and CA subdivisions of the hippocampus, and subcortical structures ...