Hot research, burning pain: the protein TRPV1 is sensitive to capsaicin, found in chili peppers. (Frontlines)Hal Cohen
In our efforts to pinpoint the non-genomic targets of testosterone, we discovered the key involvement of an ion channel protein from the transient receptor potential (TRP) superfamily of the melastatin group, TRPM8. The TRPM8 protein is expressed in various tissues, including the brain, sensory...
Transient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel that is stimulated by heat (>43 °C), mechanical/osmotic stimuli, and low pH. The importance of TRPV1 in inflammatory responses has been demonstrated, whereas its participation in brains remains unclear...
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Thermosensitive Transient Receptor Potential (TRP) channels are believed to respond to either cold or heat. In the case of TRP subtype A1 (TRPA1), there seems to be a species-dependent divergence in temperature sensation as non-mammalian TRPA1 is heat-se
A. Activation of nutritional reporter genes by PKA-MMGL interaction during direct protein-protein interaction assays. Small-scale Y2H matings between pGBKT7-MMGL and pACT2-PRKAR1A (i) and pACT2-PRKAR2A (ii) on solid medium lacking Leu, Trp, His and Ade. Growth of yeast yells indicate ...
psychrophilum was a protein of unknown function, while that from P. ingrahamii was the PriB. In P. torquis, it was a short (102 aa), single-stranded DNA binding protein without a characteristic sequence of last amino acid residues, in view of which, we omitted that protein from our ...
We have previously shown that the major surface protein of sporozoites, the circumsporozoite (CS) protein, binds specifically to salivary glands and not to other mosquito organs exposed to circulating hemolymph. In addition, a peptide from the N-terminal portion of CS protein inhibits binding of ...
(Additional file1: Figure S1). One essential functional feature ofFT-like genes is their expression in leaf vasculature and transport of the translated protein into the shoot apex. The expression ofSP5G, SP5G2andSP5G3were detected mainly in vascular tissues (Fig.2). According to the current...
Coronary TRPV1 protein levels were decreased only in DMetS (lean~MetS>DMetS). Conclusions: Capsaicin-induced relaxation of coronary conduit artery occurs via EC and TRPV1 channel signaling, which is disrupted in MetS and to a much greater extent in DMetS, suggesting lipids are important ...