We demonstrated the functional expression of TRPA1 on the plasma membrane of CD4+ T cells and identified that Trpa1(-/-) CD4+ T cells have increased T-cell receptor-induced Ca(2+) influx, activation profile and differentiation into Th1-effector cells. This phenotype was abrogated upon genetic...
nanomaterialsArticleInhibitionofTRPV1ChannelActivityinHumanCD4+TCellsbyNanodiamondandNanoplatinumLiquid,DPV576MamdoohH.Ghoneum1,*,JamesK.Gimzewski2,3,AyaGhoneum2,HidekiKatano4,ClarissaNilaPawU5andAnshuAgrawal51DepartmentofSurgery,CharlesDrewUniversityofMedicineandScience,LosAngeles,CA90059,USA2DepartmentofChemis...
Using CD4 (Trp1) and CD8 (Pmel) transgenic TCR T cells specific to B16 melanoma antigens gp75 and gp100 respectively, we demonstrate the re-expression of the opposite co-receptor following adoptive T cell transfer in B16 melanoma ... S Schad,A Chow,H Pan,... - 《Journal for Immunother...
Inflammatory Bowel Diseases (IBD) are characterized by an abnormal inflammation in the small intestine and colon and are mainly mediated by CD4+ T cells. This is why the primary strategy for treating IBD is by therapeutically targeting select CD4+ T cells. It is previously known that the Transi...
Supplementary Figure 4: Trpv1–/– and WT CD4+ T cells display similar apoptosis and proliferative response. | Nature Immunology Supplementary Figure 4: Trpv1–/– and WT CD4+ T cells display similar apoptosis and proliferative response. From: The ion channel TRPV1 regulates the activation ...
Trp-P-1, a carcinogenic heterocyclic amine, inhibits lipopolysaccharide-induced maturation and activation of human dendritic cells Author links open overlay panelJun Ho Jeon b 1, Sun Kyung Kim a 1, Jintaek Im a, Ki Bum Ahn a, Jung Eun Baik a, ...
Immunology CD4+ T cell mediated tumor immunity following transplantation of TRP-1 TCR gene modified hematopoietic stem cells INDIANA UNIVERSITY Christopher E. Touloukian HaSung PilImmunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy...
13,16 Previous study has revealed that TRPV1 is functionally expressed in CD4+ T cells and promotes the activation and pro-inflammatory properties of CD4+ T cells.14 The wide distribution of TRPV1 in immune cells suggests its role in modulating inflammatory responses. However, the reported ...
et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells. Nat Immunol 15, 1055–1063 (2014). 45. Miyamoto, R., Tokuda, M., Sakuta, T., Nagaoka, S. & Torii, M. Expression and characterization of vanilloid receptor subtype 1 in human dental...
Furthermore, TRPV1 activation is also involved in regulating immune cell activity, including the activation of CD4-positive T cells and the proinflammatory phenotype polarization of macrophages (M1)16,17. In contrast, a recent study has shown that TRPV1 modulates M1/M2 macrophage polarization and...